US 12,467,915 B2
Treated dried blood sample for detection of heavy metals in dried blood
William E. Funk, Evanston, IL (US); and Thomas McDade, Evanston, IL (US)
Assigned to Northwestern University, Evanston, IL (US)
Filed by Northwestern University, Evanston, IL (US)
Filed on Sep. 18, 2023, as Appl. No. 18/469,239.
Application 18/469,239 is a continuation of application No. 14/778,234, granted, now 11,761,948, previously published as PCT/US2014/028146, filed on Mar. 14, 2014.
Claims priority of provisional application 61/803,674, filed on Mar. 20, 2013.
Prior Publication US 2024/0003867 A1, Jan. 4, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/15 (2006.01); A61B 5/145 (2006.01); A61B 5/151 (2006.01); G01N 33/49 (2006.01); G01N 33/84 (2006.01)
CPC G01N 33/49 (2013.01) [A61B 5/14546 (2013.01); A61B 5/150022 (2013.01); A61B 5/150305 (2013.01); A61B 5/150358 (2013.01); A61B 5/150755 (2013.01); A61B 5/15142 (2013.01); G01N 33/84 (2013.01); A61B 2562/0295 (2013.01); A61B 2562/242 (2013.01)] 10 Claims
 
1. A method for analyzing a blood sample, the method comprising:
(a) treating a paper which contains a detectable level of one or more of arsenic (As), lead (Pb), mercury (Hg), and cadmium (Cd) with a solution consisting of a mixture of hydrochloric acid, nitric acid and deionized water,
(b) rinsing the treated paper of (a) with deionized water,
(c) contacting the paper of (b) with a blood sample,
(d) disposing the paper of (c) within a protective case comprising a desiccant; and
(e) analyzing the paper of (d) for heavy metals;
wherein the treating in (a) is performed under conditions such that the treated paper has detectable levels of any one or more of arsenic (As), lead (Pb), mercury (Hg), and cadmium (Cd) of no more than parts-per-trillion (ppt) as measured by inductively coupled plasma mass spectrometry (ICP-MS).