US 12,467,093 B2
Biomarkers for autism spectrum disorders
Stephen W Scherer, Toronto (CA); and John B Vincent, Toronto (CA)
Assigned to The Hospital for Sick Children, Toronto (CA); and Centre for Addiction and Mental Health, Toronto (CA)
Filed by The Hospital for Sick Children, Toronto (CA); and Centre for Addiction and Mental Health, Toronto (CA)
Filed on Jan. 21, 2022, as Appl. No. 17/581,371.
Application 16/694,314 is a division of application No. 14/630,205, filed on Feb. 24, 2015, granted, now 10,526,653, issued on Jan. 7, 2020.
Application 17/581,371 is a continuation of application No. 16/694,314, filed on Nov. 25, 2019, granted, now 11,254,984.
Application 14/630,205 is a continuation of application No. 12/681,229, abandoned, previously published as PCT/CA2008/001767, filed on Oct. 3, 2008.
Claims priority of provisional application 61/008,294, filed on Dec. 20, 2007.
Claims priority of provisional application 60/960,572, filed on Oct. 4, 2007.
Prior Publication US 2022/0136055 A1, May 5, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C12Q 1/68 (2018.01); C12Q 1/6883 (2018.01)
CPC C12Q 1/6883 (2013.01) [C12Q 2600/112 (2013.01); C12Q 2600/156 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/16 (2013.01)] 6 Claims
 
1. A method of detecting a sequence variation of a PTCHD1 gene in an individual suspected of having Autism Spectrum Disorder (ASD), the method comprising:
(a) amplifying a PTCHD1 nucleic acid in a biological sample comprising a PTCHD1 nucleic acid obtained from a human; (b) sequencing the PTCHD1 nucleic acid from the biological sample; and (c) detecting the presence of a sequence variant of PTCHD1, wherein the sequence variant of PTCHD1 is a sequence variant of PTCHD1 comprising a G to A mutation at position corresponding to position 591 of SEQ ID NO: 17.