| CPC C12N 15/861 (2013.01) [A61K 35/761 (2013.01); A61K 39/235 (2013.01); A61P 27/02 (2018.01)] | 29 Claims |

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1. A transcriptional control unit (TCU) of up to 2500 nucleotides in length comprising in a 5′ to 3′ direction:
(a) a Locus Control Region (LCR) comprising SEQ ID NO: 1, and
(b) a promoter element comprising SEQ ID NO: 3.
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