US 12,467,058 B2
Influenza virus-like particle production in plants
Manon Couture, St-Augustin-de-Desmaures (CA); Marc-Andre D'Aoust, Quebec (CA); and Louis-Philippe Vezina, Neuville (CA)
Assigned to ARAMIS BIOTECHNOLOGIES INC., Quebec (CA)
Filed by MEDICAGO INC., Quebec (CA)
Filed on Aug. 6, 2021, as Appl. No. 17/395,703.
Application 17/395,703 is a continuation in part of application No. 16/516,802, filed on Jul. 19, 2019, granted, now 11,085,049.
Application 16/516,802 is a continuation of application No. 14/779,423, granted, now 10,358,652, issued on Jul. 23, 2019, previously published as PCT/CA2014/050326, filed on Mar. 28, 2014.
Claims priority of provisional application 61/971,274, filed on Mar. 27, 2014.
Claims priority of provisional application 61/925,852, filed on Jan. 10, 2014.
Claims priority of provisional application 61/806,227, filed on Mar. 28, 2013.
Prior Publication US 2022/0145317 A1, May 12, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. C12N 15/82 (2006.01); A61K 39/00 (2006.01); A61K 39/12 (2006.01); A61K 39/145 (2006.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01)
CPC C12N 15/8258 (2013.01) [A61K 39/12 (2013.01); A61K 39/145 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); C12N 15/8257 (2013.01); A61K 2039/5258 (2013.01); A61K 2039/54 (2013.01); C07K 2319/02 (2013.01); C12N 2760/16122 (2013.01); C12N 2760/16123 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16151 (2013.01); C12N 2760/16171 (2013.01); C12N 2760/16222 (2013.01); C12N 2760/16223 (2013.01); C12N 2760/16234 (2013.01); C12N 2760/16251 (2013.01); C12N 2760/16271 (2013.01)] 15 Claims
 
1. A modified influenza type A subtype H3 hemagglutinin (HA) comprising a fully deleted proteolytic loop between subunits HA1 and HA2.