	US 12,467,042 B2
	Lipase enzyme
Christopher Moers, Münster (DE); and Ingo Aldag, Münster (DE)
Assigned to DERMAPHARM AKTIENGESELLSCHAFT, Grünwald (DE)
Appl. No. 17/999,980
Filed by DERMAPHARM AKTIENGESELLSCHAFT, Grünwald (DE)
PCT Filed Jun. 24, 2021, PCT No. PCT/EP2021/067419 § 371(c)(1), (2) Date Nov. 28, 2022, PCT Pub. No. WO2021/260148, PCT Pub. Date Dec. 30, 2021.
Claims priority of application No. 20182077 (EP), filed on Jun. 24, 2020.
Prior Publication US 2023/0220360 A1, Jul. 13, 2023
Int. Cl. C12N 9/20 (2006.01); A61K 38/46 (2006.01)

CPC C12N 9/20 (2013.01) [A61K 38/46 (2013.01)]

17 Claims

1. A lipase enzyme comprising an amino acid sequence that has at least 90% sequence identity with SEQ ID NO 1, or comprising a functional fragment thereof encompassing position Q55, with the proviso that the lipase enzyme has a substitution of an amino acid with a basic side chain at neutral pH in position Q55.