	US 12,466,881 B2
	Pre-filled syringe and method of producing pre-filled syringe
Taichi Sawaguchi, Tokyo (JP)
Assigned to ZEON CORPORATION, Tokyo (JP)
Appl. No. 17/261,870
Filed by ZEON CORPORATION, Tokyo (JP)
PCT Filed Jul. 24, 2019, PCT No. PCT/JP2019/029094 § 371(c)(1), (2) Date Jan. 21, 2021, PCT Pub. No. WO2020/026927, PCT Pub. Date Feb. 6, 2020.
Claims priority of application No. 2018-143856 (JP), filed on Jul. 31, 2018; and application No. 2018-189474 (JP), filed on Oct. 4, 2018.
Prior Publication US 2021/0292402 A1, Sep. 23, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. C07K 16/24 (2006.01); A61K 9/00 (2006.01); A61K 47/26 (2006.01); A61M 5/31 (2006.01)

CPC C07K 16/241 (2013.01) [A61M 5/3129 (2013.01); A61K 9/0019 (2013.01); A61K 47/26 (2013.01); A61M 2207/00 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01)]

12 Claims

1. A pre-filled syringe comprising:

a barrel including a nozzle at a tip thereof:

a sealing member sealing the nozzle;

a gasket slidably housed inside the barrel:

a plunger linked to the gasket and performing a movement operation of the gasket in a longitudinal direction of the barrel; and

a protein solution formulation filled into a space defined by the sealing member, the gasket, and a region that is part of an inner wall surface of the barrel, wherein

the barrel is formed of a resin, formable by the resin having oxygen concentration of 10 mass ppm or less, including at least one cycloolefin monomer unit selected from a group including a tetracyclo[7.4.0.0^2,70.1^10,13]trideca-2,4,6,11-tetraene monomer unit, a bicyclo[2.2.1]hept-2-ene monomer unit, and a 8-ethyl-tetracyclo[4.4.0.1^2,50.1^7,10]dodec-3-ene monomer unit, and

the protein solution formulation has a non-ionic surfactant concentration of more than 0 mg/mL and less than 0.05 mg/mL.