US 12,466,856 B2
Echinocandin analogues and preparation method therefor
Jian Huang, Shanghai (CN); Lingjian Zhu, Shanghai (CN); Wei Jiang, Shanghai (CN); and Weicou Cao, Shanghai (CN)
Assigned to Shanghai Senhui Medicine Co., Ltd., Shanghai (CN); Shanghai Shengdi Pharmaceutical Co., Ltd., Shanghai (CN); and Jiangsu Hengrui Medicine Co., Ltd., Lianyungang Jiangsu (CN)
Appl. No. 17/756,721
Filed by SHANGHAI SENHUI MEDICINE CO., LTD., Shanghai (CN); SHANGHAI SHENGDI PHARMACEUTICAL CO., LTD., Shanghai (CN); and JIANGSU HENGRUI MEDICINE CO., LTD., Jiangsu (CN)
PCT Filed Dec. 4, 2020, PCT No. PCT/CN2020/133815
§ 371(c)(1), (2) Date Jun. 1, 2022,
PCT Pub. No. WO2021/110125, PCT Pub. Date Jun. 10, 2021.
Claims priority of application No. 201911241526.8 (CN), filed on Dec. 6, 2019; application No. 201911249226.4 (CN), filed on Dec. 9, 2019; application No. 202010165349.6 (CN), filed on Mar. 11, 2020; application No. 202010799506.9 (CN), filed on Aug. 11, 2020; application No. 202011164541.X (CN), filed on Oct. 27, 2020; and application No. 202011371550.6 (CN), filed on Nov. 30, 2020.
Prior Publication US 2023/0159591 A1, May 25, 2023
Int. Cl. C07K 7/56 (2006.01); A61P 31/10 (2006.01)
CPC C07K 7/56 (2013.01) [A61P 31/10 (2018.01)] 6 Claims
 
1. A compound of formula I or a pharmaceutically acceptable salt or isomer thereof,

OG Complex Work Unit Chemistry
wherein R1 is selected from the group consisting of:

OG Complex Work Unit Chemistry
R2 is selected from the group consisting of hydrogen, RB1RB2N—, CH2CH2NRB1RB2, CH2C(O)NRB1RB2, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, aryl, heteroaryl, cyclohydrocarbyl, heterocyclyl and PEG, wherein said PEG is polyethylene glycol;
R3 is selected from the group consisting of H, OSO3H and CH2NRB1RB2;
G is a C10-36 lipophilic unit, or

OG Complex Work Unit Chemistry
RB1 and RB2 are independently selected from the group consisting of H, —C(O)RJ and C1-10 alkyl; and
RJ is independently selected from the group consisting of hydrogen, deuterium, C1-10 alkyl, cyclohydrocarbyl and cyclohydrocarbylene.