US 12,466,843 B2
Gadolinium-based compound, method for producing same, and MRI contrast agent containing same
Yong Min Chang, Daegu (KR); and So Yeon Kim, Daegu (KR)
Assigned to KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Busan (KR)
Appl. No. 17/755,143
Filed by KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Busan (KR)
PCT Filed Sep. 29, 2020, PCT No. PCT/KR2020/013347
§ 371(c)(1), (2) Date Apr. 21, 2022,
PCT Pub. No. WO2021/085875, PCT Pub. Date May 6, 2021.
Claims priority of application No. 10-2019-0134992 (KR), filed on Oct. 29, 2019; and application No. 10-2020-0114620 (KR), filed on Sep. 8, 2020.
Prior Publication US 2022/0380386 A1, Dec. 1, 2022
Int. Cl. C07F 5/00 (2006.01); A61K 49/10 (2006.01)
CPC C07F 5/00 (2013.01) [A61K 49/108 (2013.01)] 20 Claims
 
1. A gadolinium-based compound represented by a following Chemical Formula 1:

OG Complex Work Unit Chemistry
wherein in the Chemical Formula 1,
A represents *—(CH2)n-A1-*,
n represents any integer from 0 to 5,
A1 represents *—COO—*, *—CO—*, *—NR1—*, *—CH2—*, *—CONH—*, or *—O—*,
Linker represents *-L1-NHCO-L2-*, *-L1-O—R2—O-L2-*, *-L1-CH2-L2-*, *-L1-NR3-L2-* or *-L1-COO-L2-*,
each of L1 and L2 independently represents linear or branched (C1-C30)alkyl,
each of R1 and R3 independently represents hydrogen or linear or branched (C1-C10)alkyl,
R2 represents linear or branched (C1-C20)alkyl,
RB represents a following Chemical Formula 2:

OG Complex Work Unit Chemistry
* indicates a connection site,
wherein the gadolinium-based compound is capable of binding vesicular glutamate transporter (VGLUT).