US 12,466,811 B2
Mass spectrometry cleavable heterobifunctional photoactivated cross-linkers
Lan Huang, Irvine, CA (US); and Scott D. Rychnovsky, Irvine, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Filed by The Regents of the University of California, Oakland, CA (US)
Filed on Feb. 24, 2022, as Appl. No. 17/680,236.
Claims priority of provisional application 63/153,344, filed on Feb. 24, 2021.
Prior Publication US 2022/0274963 A1, Sep. 1, 2022
Int. Cl. C07D 403/12 (2006.01); G01N 30/72 (2006.01); G01N 33/68 (2006.01); G01N 30/02 (2006.01)
CPC C07D 403/12 (2013.01) [G01N 30/7233 (2013.01); G01N 33/6845 (2013.01); G01N 33/6848 (2013.01); G01N 2030/027 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A MS-cleavable heterobifunctional photoactivated cross-linker having a structure selected from:

OG Complex Work Unit Chemistry
wherein the dashed line indicates a MS-cleavable bond, and
wherein the MS-cleavable cross-linker is configured for mapping intra-protein interactions in a protein, or inter-protein interactions in a protein complex, or combinations thereof.