US 12,466,798 B2
Process for the preparation of fluensulfone
Ronny Neumann, Kfar Saba (IL); and Alexander Khenkin, Rehovot (IL)
Assigned to YEDA RESEARCH AND DEVELOPMENT CO. LTD., Rehovot (IL)
Appl. No. 17/630,523
Filed by YEDA RESEARCH AND DEVELOPMENT CO. LTD., Rehovot (IL)
PCT Filed Aug. 4, 2020, PCT No. PCT/IL2020/050852
§ 371(c)(1), (2) Date Jan. 27, 2022,
PCT Pub. No. WO2021/024253, PCT Pub. Date Feb. 11, 2021.
Claims priority of provisional application 62/882,541, filed on Aug. 4, 2019.
Prior Publication US 2022/0242838 A1, Aug. 4, 2022
Int. Cl. C07D 277/36 (2006.01)
CPC C07D 277/36 (2013.01) 22 Claims
 
1. A method for the preparation of a compound represented by the structure of Formula (I):

OG Complex Work Unit Chemistry
comprising a step of contacting in a reaction mixture a compound of Formula (Ia):

OG Complex Work Unit Chemistry
wherein, R is a heterocyclic ring selected from thiophene, thiazole, isothiazole, thiadiazole and thiatriazole, wherein the heterocyclic ring is optionally halogenated;
and n is an integer between 1 and 6;
with a peroxygen oxidant in an acidic aqueous phase in the presence of a catalyst, wherein the acidic aqueous phase comprises HCl, HBr, H2SO4, H3PO4, MeSO3H, CF3SO3H or combination thereof.