US 12,466,784 B2
Analogs of pterostilbene amino acid bearing carbonates for treating a non-alcoholic fatty liver disease and nonalcoholic steatohepatitis
Tai-Huang Kuo, Tainan (TW); Po-Chuen Shieh, Kaohsiung (TW); Ming-Long Cheng, Taoyuan (TW); and Chih-Wei Fu, Hsinchu (TW)
Assigned to APICAL MOLECULAR BIOTECH CO., LTD., Taoyuan (TW)
Appl. No. 18/009,793
Filed by APICAL MOLECULAR BIOTECH CO., LTD., Taoyuan (TW)
PCT Filed Jun. 8, 2021, PCT No. PCT/CN2021/098765
§ 371(c)(1), (2) Date Dec. 12, 2022,
PCT Pub. No. WO2021/249364, PCT Pub. Date Dec. 16, 2021.
Claims priority of provisional application 63/038,142, filed on Jun. 12, 2020.
Prior Publication US 2023/0234912 A1, Jul. 27, 2023
Int. Cl. C07C 229/10 (2006.01); C07C 229/26 (2006.01); C07C 237/20 (2006.01); C07C 271/06 (2006.01); C07C 323/60 (2006.01)
CPC C07C 229/10 (2013.01) [C07C 229/26 (2013.01); C07C 237/20 (2013.01); C07C 271/06 (2013.01); C07C 323/60 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A compound having the following formula:

OG Complex Work Unit Chemistry
wherein n is 1 to 3;
mis 2 to 6;
Q, X and Y independently are O, S, or NH;
Ra, Rb, and Rc independently are H, halogen, C1-C6 linear alkyl, C1-C6 linear alkoxy, C3-C6 branched alkyl, C3-C6 branched alkoxy or C1-C6 fluoroalkoxy;
Rd and Re independently are H, halogen, C1-C6linear alkyl, C1-C6 linear alkoxy, C3-C6 branched alkyl, C3-C6 branched alkoxy or C1-C6 fluoroalkoxy, or Rd and Re are linked to form a ring structure, so that

OG Complex Work Unit Chemistry
wherein j is 1 to 3; or
a pharmaceutically acceptable salt thereof.