US 12,466,781 B2
Thyromimetics
Thomas von Geldern, Richmond, IL (US); Bradley Backes, San Francisco, CA (US); Baoku He, Jiangsu (CN); and Jason Harris, San Diego, CA (US)
Assigned to AUTOBAHN THERAPEUTICS, INC., San Diego, CA (US)
Appl. No. 17/780,465
Filed by Autobahn Therapeutics, Inc., San Diego, CA (US)
PCT Filed Nov. 25, 2020, PCT No. PCT/US2020/062229
§ 371(c)(1), (2) Date May 26, 2022,
PCT Pub. No. WO2021/108549, PCT Pub. Date Jun. 3, 2021.
Claims priority of application No. PCT/CN2019/122062 (WO), filed on Nov. 29, 2019; and application No. PCT/CN2020/085540 (WO), filed on May 1, 2020.
Prior Publication US 2023/0048992 A1, Feb. 16, 2023
Int. Cl. C07C 69/734 (2006.01); A61P 11/00 (2006.01); C07C 59/70 (2006.01); C07C 235/74 (2006.01); C07C 243/18 (2006.01); C07C 259/06 (2006.01); C07D 205/04 (2006.01); C07D 261/14 (2006.01)
CPC C07C 69/734 (2013.01) [A61P 11/00 (2018.01); C07C 59/70 (2013.01); C07C 235/74 (2013.01); C07C 243/18 (2013.01); C07C 259/06 (2013.01); C07D 205/04 (2013.01); C07D 261/14 (2013.01)] 20 Claims
 
1. A compound having the structure of Formula (I):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable hydrate, solvate, isotope, or salt thereof, wherein:
X1 is lower alkyl, lower alkenyl, lower haloalkyl, or halo;
X2 is lower alkyl, lower alkenyl, lower haloalkyl, or halo;
Y1 and Y2 are each, independently, H, cyano, halogen, lower alkyl, or lower alkoxy, wherein at least one of Y1 and Y2 is not H;
R1 is —NR1aR1b or —OR1c;
R1a and R1b are each, independently, H, lower alkyl, lower alkenyl, lower alkynyl, carbocycle, carbocyclealkyl, heterocycle, or heterocyclealkyl, or R1a and R1b taken together with the nitrogen atom to which they are attached form heterocycle;
R1c is H, lower alkyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl; and
R2 is lower alkyl, lower alkenyl, carbocycle, heterocycle, carbocyclealkyl, or heterocyclealkyl;
wherein R1a, R1b, R1c, and R2 are each, independently, optionally substituted with one or more halo, lower alkyl, lower haloalkyl, cyano, —OR′, —NR′R″, ═O, ═S, —S(O)2R′ or —S(O)2OR′, wherein R′ and R″ are each, independently, H, lower alkyl, or lower haloalkyl.