US 12,466,779 B2
Method for obtaining oleacein and oleomissional type secoiridoids and for producing respective pharmaceutical preparations
Prokopios Magiatis, Ampelakia Attikis (GR); Eleni Melliou, Ampelakia Attikis (GR); Panagiotis Diamantakos, Voula Attikis (GR); and Aimilia Rigakou, Xirokampi Lakonias (GR)
Assigned to OMPHAX SA, Ano Liosia (GR)
Appl. No. 17/430,467
Filed by OMPHAX SA, Ano Liosia (GR)
PCT Filed Feb. 11, 2020, PCT No. PCT/GR2020/000014
§ 371(c)(1), (2) Date Aug. 12, 2021,
PCT Pub. No. WO2020/165613, PCT Pub. Date Aug. 20, 2020.
Claims priority of application No. 20190100075 (GR), filed on Feb. 13, 2019.
Prior Publication US 2022/0119335 A1, Apr. 21, 2022
Int. Cl. C07C 67/31 (2006.01); A23L 33/10 (2016.01); A61K 31/7048 (2006.01); C07C 67/56 (2006.01); C07C 69/738 (2006.01)
CPC C07C 67/31 (2013.01) [A23L 33/10 (2016.08); A61K 31/7048 (2013.01); C07C 67/56 (2013.01); C07C 69/738 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method for obtaining secoiridoids of type

OG Complex Work Unit Chemistry
according to which:
plant material from the species Olea europaea L, including all subspecies and cultivars, is brought into contact with a solvent, said solvent comprising water or a water immiscible organic solvent, at a ratio ranging from 1:1 to 1:20 at a temperature of 15-40° C., left in contact for a time period ranging from 30 minutes to 12 hours, to activate at said temperature a reaction of an enzyme with oleuropein, said enzyme and oleuropein present in said plant material, and generate a mixture (A).