| CPC B01J 19/0046 (2013.01) [G16B 25/30 (2019.02); B01J 2219/00585 (2013.01); B01J 2219/00596 (2013.01); B01J 2219/00608 (2013.01); B01J 2219/00722 (2013.01)] | 15 Claims |
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1. A method for microarray transformation comprising:
a) providing a template array, wherein the template array comprises multiple spots comprising RNA or DNA template molecules wherein the multiple spots have a first shape, a first size and a first position of the multiple spots on the template array,
b) providing a cavity chip comprising a transfer matrix comprising an array surface including an arrangement of cavities,
c) providing a reaction mixture in the cavities of the cavity chip, and
d) subsequent to c), placing the template array onto the cavity chip, and
e) copying the RNA or DNA template molecules of the multiple spots of the template array onto the cavity chip resulting in spots in the cavities of the cavity chip so that the cavities comprise the RNA or DNA template molecules and the reaction mixture,
f) providing a second array surface,
g) repeating c),
h) subsequent to g), placing the second array surface of f) onto the cavity chip,
i) copying the spots of e) of the cavity chip onto the second array surface resulting in a second array comprising,
multiple spots on the second array having a second shape, a second size and a second position, wherein at least one of the second shape, second size and second position of the multiple spots on the second array differs from the first shape, first size and first position of the multiple spots on the template array, wherein the second position on the second array comprises a spatial transformation shift relative to the first position on the template array.
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