US 12,465,780 B2
Adjusting tumor treating fields simulation and treatment using molecular imaging
Tali Voloshin-Sela, Haifa (IL); Lilach Avigdor, Haifa (IL); and Reuven Ruby Shamir, Haifa (IL)
Assigned to Novocure GmbH, Baar (CH)
Filed by Novocure GmbH, Root (CH)
Filed on Oct. 17, 2022, as Appl. No. 17/967,018.
Claims priority of provisional application 63/278,643, filed on Nov. 12, 2021.
Prior Publication US 2023/0149728 A1, May 18, 2023
Int. Cl. A61N 1/40 (2006.01); C12Q 1/00 (2006.01)
CPC A61N 1/40 (2013.01) [C12Q 1/005 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A computer-implemented method to determine placement of transducers on a subject's body for applying tumor treating fields, the computer comprising one or more processors and memory accessible by the one or more processors, the memory storing instructions that when executed by the one or more processors cause the computer to perform the method, the method comprising:
determining a first pair of locations on the subject's body for placement of a pair of transducer arrays based on image data of the subject's body;
receiving a detected concentration of a target molecule within a target region of the subject's body from a molecular imaging apparatus, the concentration of the target molecule being detected after tumor treating fields are induced between the pair of transducer arrays located at the first pair of locations;
determining, based on the detected concentration of the target molecule, a distribution of the tumor treating fields in the target region of the subject's body;
determining a recommendation of a second pair of locations on the subject's body for placement of the pair of transducer arrays based on the distribution of the tumor treating fields in the target region of the subject's body; and
outputting the recommendation of the second pair of locations to a user.