US 12,465,766 B2
System and methods to deliver hyperpolarizing waveform
Hyun-Joo Park, Frisco, TX (US)
Assigned to Advanced Neuromodulation Systems, Inc., Plano, TX (US)
Filed by Advanced Neuromodulation Systems, Inc., Plano, TX (US)
Filed on Nov. 3, 2022, as Appl. No. 17/980,325.
Claims priority of provisional application 63/276,020, filed on Nov. 5, 2021.
Prior Publication US 2023/0144889 A1, May 11, 2023
Int. Cl. A61N 1/36 (2006.01)
CPC A61N 1/36071 (2013.01) [A61N 1/36062 (2017.08); A61N 1/36178 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A method of providing a neurostimulation therapy to treat pain in a patient, comprising:
generating electrical pulses, by an implantable pulse generator (IPG), comprising respective anodic bursts of a plurality of anodic pulses with each anodic pulse within each respective anodic burst being separated by a time gap, wherein (1) each anodic pulse within each respective anodic burst comprises successively increasing charge and incrementally increases a hyperpolarization state of neural tissue through the respective anodic burst, wherein the hyperpolarization state is maintained during each respective anodic burst; (2) the plurality of anodic pulses are charge limited to be sub-threshold; (3) each respective anodic burst is followed by a discharge phase of a respective cathodic burst of a plurality of cathodic pulses with each cathodic pulse of the plurality of cathodic pulses being separated by a time gap, wherein the discharge phase discharges the hyperpolarization state while the plurality of cathodic pulses are charged limited to avoid action potential (AP) generation; and
applying the generated electrical pulses to neural tissue of the patient to inhibit neural activity of the patient to treat pain of the patient.