| CPC A61N 1/36031 (2017.08) [A61N 1/0456 (2013.01); A61N 1/0476 (2013.01); A61N 1/36034 (2017.08); G16H 20/30 (2018.01)] | 20 Claims |

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1. A non-transitory computer-readable medium storing instructions which, when executed by one or more processors of a system for nerve modulation in a residual limb of an amputee, cause the system to:
display a graphical user interface of a user device including an external controller to receive one or more inputs from the amputee;
receive, from the amputee with the graphical user interface, a first input to directly and selectively activate at least one of a plurality of electrodes of a polymer substrate that are in electrical contact with the amputee's skin of the residual limb,
the plurality of electrodes coupled with an electrode controller via respective conductive paths and an interconnect in communication with the user device,
the interconnect configured for the amputee to interchangeably connect the electrode controller and the substrate when coupled with the conductive paths;
receive, from the graphical user interface, a second input associated with at least one of a tapping sensation, a kneading sensation, a rolling sensation, a cupping sensation, or a scraping sensation;
transmit, with the external controller to the electrode controller, signaling indicating to transmit electrical current to the directly and selectively activated electrodes at one or more locations according to the first input and the second input; and
electrically simulate the at least one sensation and stimulate nerve fibers in the residual limb responsive to transmitting the electrical current.
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