US 12,465,718 B2
Methods and devices for modulation of integrated neural networks to influence composite sensory processes
Daniel Z. Wetmore, Brooklyn, NY (US); and William J. Tyler, Cave Creek, AZ (US)
Assigned to IST, LLC, Dover, DE (US)
Appl. No. 17/423,741
Filed by IST, LLC, Dover, DE (US)
PCT Filed Jan. 21, 2020, PCT No. PCT/US2020/014442
§ 371(c)(1), (2) Date Jul. 16, 2021,
PCT Pub. No. WO2020/150737, PCT Pub. Date Jul. 23, 2020.
Claims priority of provisional application 62/794,394, filed on Jan. 18, 2019.
Prior Publication US 2022/0160995 A1, May 26, 2022
Int. Cl. A61M 21/02 (2006.01); A61N 1/04 (2006.01); A61N 1/36 (2006.01)
CPC A61M 21/02 (2013.01) [A61N 1/0472 (2013.01); A61N 1/36025 (2013.01); A61N 1/36034 (2017.08); A61N 1/36036 (2017.08)] 19 Claims
OG exemplary drawing
 
16. A method of treating insomnia, the method comprising:
inserting a first low-impedance hydrogel into a subject's first ear canal in a manner that the first low-impedance hydrogel expands to contact a wall of the first ear canal, wherein the first low-impedance hydrogel comprises a first electrical contact;
inserting a second low-impedance hydrogel into the subject's second ear canal in a manner that the second low-impedance hydrogel expands to contact a wall of the second ear canal, wherein the second low-impedance hydrogel comprises a second electrical contact; and
increasing drowsiness by applying a treatment electrical signal between the first and second electrical contacts for at least 10 minutes before the subject's target bedtime, wherein the treatment electrical signal comprises a biphasic, pulsed signal having a frequency of greater than 200 Hertz (Hz), in a manner that the wall of the first ear canal receives a current density of >2 Milliampere per square centimeter (mA/cm2); and
applying a second electrical signal between the first and second low-impedance hydrogels, wherein the second electrical signal comprises a biphasic, pulsed signal having a frequency of greater than 200 Hz.