US 12,465,685 B2
Closed-loop artificial pancreas device with integrated detection and infusion
Cuijun Yang, Shanghai (CN)
Assigned to MEDTRUM TECHNOLOGIES INC., Shanghai (CN)
Appl. No. 17/611,575
Filed by MEDTRUM TECHNOLOGIES INC., Shanghai (CN)
PCT Filed Dec. 31, 2019, PCT No. PCT/CN2019/130423
§ 371(c)(1), (2) Date Nov. 16, 2021,
PCT Pub. No. WO2021/012621, PCT Pub. Date Jan. 28, 2021.
Claims priority of application No. PCT/CN2019/096673 (WO), filed on Jul. 19, 2019.
Prior Publication US 2022/0193339 A1, Jun. 23, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61M 5/14 (2006.01); A61B 5/00 (2006.01); A61B 5/145 (2006.01); A61B 5/1473 (2006.01); A61F 2/02 (2006.01); A61M 5/142 (2006.01); A61M 5/145 (2006.01); A61M 5/158 (2006.01); A61M 5/172 (2006.01); A61M 5/20 (2006.01); G16H 20/17 (2018.01); G16H 40/63 (2018.01)
CPC A61M 5/1723 (2013.01) [A61B 5/14532 (2013.01); A61B 5/1473 (2013.01); A61B 5/4839 (2013.01); A61F 2/022 (2013.01); A61M 5/14236 (2013.01); A61M 5/14244 (2013.01); A61M 5/14248 (2013.01); A61M 5/1452 (2013.01); A61M 5/1454 (2013.01); A61M 5/158 (2013.01); A61M 5/172 (2013.01); G16H 20/17 (2018.01); G16H 40/63 (2018.01); A61B 2560/0209 (2013.01); A61B 2562/043 (2013.01); A61M 5/1413 (2013.01); A61M 2005/14208 (2013.01); A61M 2005/14252 (2013.01); A61M 2005/14268 (2013.01); A61M 2005/14506 (2013.01); A61M 2005/1585 (2013.01); A61M 2005/1726 (2013.01); A61M 2005/2006 (2013.01); A61M 2205/0216 (2013.01); A61M 2205/0233 (2013.01); A61M 2205/0266 (2013.01); A61M 2205/33 (2013.01); A61M 2205/3317 (2013.01); A61M 2205/3327 (2013.01); A61M 2205/3553 (2013.01); A61M 2205/3576 (2013.01); A61M 2205/3592 (2013.01); A61M 2205/50 (2013.01); A61M 2205/502 (2013.01); A61M 2209/088 (2013.01); A61M 2230/005 (2013.01); A61M 2230/20 (2013.01); A61M 2230/201 (2013.01)] 15 Claims
OG exemplary drawing
 
1. A closed-loop artificial pancreas device with integrated detection and infusion, comprising:
an infusion unit configured to deliver drugs, wherein the infusion unit includes a drug storage unit, a metal piece, a piston and a rigid screw, the piston is arranged in the drug storage unit, the metal piece is fixedly connected to the rigid screw and is arranged on the piston;
at least one position detector, wherein the metal piece and the at least one position detector interact to a generate electrical or a magnetic signal;
a program unit comprising an input end and at least one output end, and the input end comprising a plurality of electrically connective regions for receiving a signal of an analyte data in a body fluid, after the at least one output end is electrically connected to the infusion unit, according to a received signal of the analyte data in the body fluid, the program unit controls whether the infusion unit delivers the drugs;
an infusion cannula with at least one conductive area, wherein the infusion cannula is an infusion channel; and
a plurality of electrodes for detecting the analyte data in the body fluid, the electrodes comprising at least one conductive-area electrode and a cannula-wall electrode, the at least one conductive area of the infusion cannula being the at least one conductive- area electrode, wherein when the infusion cannula is installed to a working position, the infusion cannula is connected with the infusion unit, the drugs are capable of being injected into a body through the infusion cannula, and the electrodes are electrically connected to the electrically connective regions respectively, inputting signal of the analyte data in the body fluid to the program unit,
wherein the infusion cannula includes an infusion steel needle and a hose which is placed on an outer wall surface of the infusion steel needle, and a needle cavity of the infusion steel needle is used for infusion of the drugs,
when the drugs are injected through the infusion cannula, the infusion cannula is installed to the working position, the infusion steel needle does not retract, a depth of the hose into a skin is d1, while a depth of the infusion steel needle into the skin is d2, d1 ≤ d2, and d1>0,
wherein when the infusion cannula is installed to the working position, the at least one conductive-area electrode and the cannula-wall electrode are directly electrically connected to the electrically connective regions, respectively,
wherein the infusion steel needle is the at least one conductive-area electrode,
wherein the cannula-wall electrode is located on the outer wall surface of the infusion steel needle.