US 12,465,668 B2
Organic solvent free compositions comprising protein-polymer conjugates and uses thereof
Yonatan Shachaf, Haifa (IL); Raz Simon, Kibbutz Alonim (IL); and Koby Gvili, Nesher (IL)
Assigned to REGENTIS BIOMATERIALS LTD., Or-Akiva (IL)
Filed by REGENTIS BIOMATERIALS LTD., Or-Akiva (IL)
Filed on Dec. 17, 2021, as Appl. No. 17/554,720.
Application 17/554,720 is a continuation of application No. 16/062,497, abandoned, previously published as PCT/IL2016/051333, filed on Dec. 14, 2016.
Claims priority of application No. PCT/IL2015/051228 (WO), filed on Dec. 17, 2015.
Prior Publication US 2022/0105240 A1, Apr. 7, 2022
Int. Cl. A61L 27/26 (2006.01); A61K 47/58 (2017.01); A61K 47/60 (2017.01); A61L 27/18 (2006.01); A61L 27/22 (2006.01); A61L 27/36 (2006.01); A61L 27/46 (2006.01); A61L 27/52 (2006.01)
CPC A61L 27/26 (2013.01) [A61K 47/58 (2017.08); A61K 47/60 (2017.08); A61L 27/18 (2013.01); A61L 27/22 (2013.01); A61L 27/225 (2013.01); A61L 27/3687 (2013.01); A61L 27/46 (2013.01); A61L 27/52 (2013.01); A61L 2430/40 (2013.01)] 19 Claims
 
1. A ready for use kit comprising:
a stable ready for use liquid formulation in a non-crosslinked form, comprising a mixture of a protein-polymer conjugate composition and at least one polymerization initiator agent,
wherein the protein-polymer conjugate composition comprises an extracellular matrix (ECM) protein covalently bound to a synthetic polymer, wherein the synthetic polymer contains at least one polymerizable group; and
a sealed container selected from the group consisting of a single vial aliquot and a pre-filled syringe; wherein the liquid formulation comprising the mixture is stored within the sealed container in the kit under ultraviolet-visible (UV-vis) light protected conditions in a pre-gelated form so that the liquid formulation inside the container does not form a hydrogel by polymerization or crosslinking.