	US 12,465,667 B2
	Method of manufacturing and dermal filler compositions containing hyaluronic acid and hydroxyapatite
Haim Dvir, Nesher (IL)
Assigned to E.N.A. IMPECCABLE SKINCARE SOLUTIONS LTD, Nesher (IL)
Appl. No. 16/498,766
Filed by E.N.A. IMPECCABLE SKINCARE SOLUTIONS LTD, Nesher (IL)
PCT Filed Oct. 9, 2018, PCT No. PCT/IB2018/057822 § 371(c)(1), (2) Date Sep. 27, 2019, PCT Pub. No. WO2019/073386, PCT Pub. Date Apr. 18, 2019.
Claims priority of provisional application 62/570,189, filed on Oct. 10, 2017.
Prior Publication US 2020/0038552 A1, Feb. 6, 2020
Int. Cl. A61L 27/20 (2006.01); A61L 27/12 (2006.01)

CPC A61L 27/20 (2013.01) [A61L 27/12 (2013.01); A61L 2400/06 (2013.01); A61L 2400/18 (2013.01); A61L 2430/34 (2013.01)]

18 Claims

1. A composition comprising a polysaccharide covalently bonded to particulate hydroxyapatite (HAp) pretreated with organofunctional silane,

wherein the particulate HAp pretreated with organofunctional silane comprises domains that are organofunctional silane treated and domains that are free of organofunctional silane and a polysaccharide covalently bonded to the domains that are organofunctional silane treated,

wherein the domains that are free of organofunctional silane are not covalently bonded to the polysaccharide, and

wherein chains of the polysaccharide are cross-linked by the particulate HAp pretreated with organofunctional silane.