US 12,465,642 B2
Targeting microbubbles
Robert H. Grubbs, South Pasadena, CA (US); Marshall L. Stoller, San Francisco, CA (US); Hoyong Chung, Pasadena, CA (US); Alissa M. Fitzgerald, San Francisco, CA (US); Thomas W. Kenny, San Francisco, CA (US); and Renee M. Thomas, Gainesville, FL (US)
Assigned to California Institute of Technology, Pasadena, CA (US); and The Regents of the University of California, Oakland, CA (US)
Filed by California Institute of Technology, Pasadena, CA (US); and The Regents of the University of California, Oakland, CA (US)
Filed on Mar. 22, 2023, as Appl. No. 18/187,878.
Application 16/154,677 is a division of application No. 15/199,710, filed on Jun. 30, 2016, granted, now 10,149,906, issued on Dec. 11, 2018.
Application 15/199,710 is a division of application No. 13/593,747, filed on Aug. 24, 2012, abandoned.
Application 18/187,878 is a continuation of application No. 17/544,630, filed on Dec. 7, 2021, granted, now 11,642,410.
Application 17/544,630 is a continuation of application No. 16/431,605, filed on Jun. 4, 2019, granted, now 11,224,655, issued on Jan. 18, 2022.
Application 16/431,605 is a continuation of application No. 16/154,677, filed on Oct. 8, 2018, granted, now 10,357,565, issued on Jul. 23, 2019.
Claims priority of provisional application 61/527,031, filed on Aug. 24, 2011.
Prior Publication US 2023/0285561 A1, Sep. 14, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 41/00 (2020.01); A61B 17/22 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 9/107 (2006.01); A61K 31/663 (2006.01); A61K 47/24 (2006.01); A61K 47/69 (2017.01); A61N 7/00 (2006.01)
CPC A61K 41/0028 (2013.01) [A61B 17/22004 (2013.01); A61B 17/2202 (2013.01); A61B 17/22022 (2013.01); A61K 9/0009 (2013.01); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 9/1075 (2013.01); A61K 31/663 (2013.01); A61K 41/0033 (2013.01); A61K 47/24 (2013.01); A61K 47/6911 (2017.08); A61N 7/00 (2013.01); A61B 2017/22007 (2013.01); A61B 2017/22008 (2013.01); A61K 2121/00 (2013.01); A61N 2007/0039 (2013.01)] 20 Claims
 
1. A method of fragmenting a target within a patient comprising:
(a) administering microbubbles to the patient, the microbubbles comprising (i) gas, and (ii) a targeting moiety, wherein the targeting moiety comprises a bisphosphonate;
(b) concentrating the microbubbles on or near the target; and
(c) fragmenting the target by applying ultrasound or electromagnetic energy to the microbubbles within the patient, wherein the target is a urinary stone, a biliary stone, a kidney stone, a blood clot, a fibroid, or atheromatous plaque.