US 12,465,626 B2
Traditional Chinese medicine composition with improving cognition effect, preparation method thereof and traditional Chinese medicine preparation
Shengcan Zou, Qingdao (CN); Shanglong Wang, Qingdao (CN); Xin Li, Qingdao (CN); Lei Zong, Qingdao (CN); Jiancheng Zong, Qingdao (CN); and Zengliang Zhang, Qingdao (CN)
Assigned to Qingdao Chenland Health Industry Group Co., Ltd., Qingdao (CN); and Chenland Nutritionals, Inc., Irvine, CA (US)
Filed by Chenland Nutritionals, Inc., Irvine, CA (US); and Qingdao Chenland Biological Technology Co., ltd., Qingdao (CN)
Filed on Mar. 12, 2022, as Appl. No. 17/693,327.
Application 17/693,327 is a continuation of application No. PCT/CN2019/126530, filed on Dec. 19, 2019.
Claims priority of application No. 201911113149.X (CN), filed on Nov. 14, 2019.
Prior Publication US 2022/0226413 A1, Jul. 21, 2022
Int. Cl. A61K 36/00 (2006.01); A61K 36/64 (2006.01); A61K 36/69 (2006.01); A61K 36/882 (2006.01); A61K 36/8988 (2006.01); A61K 47/69 (2017.01)
CPC A61K 36/69 (2013.01) [A61K 36/64 (2013.01); A61K 36/882 (2013.01); A61K 36/8988 (2013.01); A61K 47/6951 (2017.08); A61K 2236/331 (2013.01); A61K 2236/333 (2013.01); A61K 2236/37 (2013.01); A61K 2236/53 (2013.01)] 4 Claims
 
1. A traditional Chinese medicine composition with improving cognition effect, wherein the traditional Chinese medicine composition is made from following raw materials:
16-20 parts by weight of Gastrodiae rhizoma, 10-14 parts by weight of Polygala tenuifolia Willd., 16-20 parts by weight of Acorus tatarinowii, 5-7 parts by weight of Cistanche deserticola Ma, 5-7 parts by weight of Rehmanniae radix praeparata, and 0.05-0.15 parts by weight of curcumin;
wherein the traditional Chinese medicine composition is prepared by a method comprising the following steps:
ethanol extraction: heating and refluxing Gastrodiae rhizoma and Polygala tenuifolia Willd. with ethanol aqueous solution, and collecting an ethanol extraction solution and an ethanol extraction residue;
water extraction: heating and refluxing Acorus tatarinowii with water, and collecting Acorus tatarinowii solution, Acorus tatarinowii residue and Acorus tatarinowii volatile oil; heating and refluxing Cistanche deserticola Ma, Rehmanniae radix praeparata, the ethanol extraction residue, the Acorus tatarinowii residue with water, and collecting a water extraction solution;
filtration and concentration: mixing the ethanol extraction solution, the Acorus tatarinowii solution and the water extraction solution to obtain a mixing solution, and filtrating and concentrating the mixing solution to obtain an extractum;
encapsulation: mixing the Acorus tatarinowii volatile oil and curcumin, and obtaining micropellets by cyclodextrin encapsulating; and
mixing: mixing the extractum and the micropellets.