	US 12,465,585 B2
	Compositions for the management of seizure induced neurotoxicity
Muhammed Majeed, Bangalore (IN); and Kalyanam Nagabhushanam, East Windsor, NJ (US)
Assigned to SAMI-SABINSA GROUP LIMITED, Bangalore (IN)
Filed by Muhammed Majeed, Bangalore (IN); and Kalyanam Nagabhushanam, East Windsor, NJ (US)
Filed on Jul. 1, 2021, as Appl. No. 17/365,519.
Application 17/365,519 is a continuation in part of application No. 16/801,257, filed on Feb. 26, 2020, abandoned.
Application 16/801,257 is a continuation in part of application No. 16/441,465, filed on Jun. 14, 2019, granted, now 10,959,980, issued on Mar. 30, 2021.
Claims priority of provisional application 62/685,400, filed on Jun. 15, 2018.
Prior Publication US 2021/0322370 A1, Oct. 21, 2021
Int. Cl. A61K 31/353 (2006.01); A61K 9/00 (2006.01); A61P 25/08 (2006.01)

CPC A61K 31/353 (2013.01) [A61K 9/0053 (2013.01); A61P 25/08 (2018.01)]

4 Claims

1. A method for preventing apoptosis in neuronal cells of mammals with epilepsy, said method comprising step of: a) identifying a mammal with signs and features of neurotoxicity induced by seizures and b) administering effective concentration of a composition comprising not less than 10% w/w of oroxylin A, not less than 10% w/w of baicalein and not less than 2% w/w of chrysin, to said mammals to prevent apoptosis of neurons.