US 12,465,580 B2
Substituted fatty acids for treating non-alcoholic steatohepatitis
Hilde Steineger, Oslo (NO); David Alan Fraser, Blommenholm (NO); and Tore Skjæret, Oslo (NO)
Assigned to BASF AS, Oslo (NO)
Filed by BASF AS, Oslo (NO)
Filed on Jan. 17, 2024, as Appl. No. 18/414,988.
Application 18/414,988 is a continuation of application No. 17/551,673, filed on Dec. 15, 2021, granted, now 11,911,354.
Application 17/551,673 is a continuation of application No. 16/532,633, filed on Aug. 6, 2019, granted, now 11,234,948, issued on Feb. 1, 2022.
Application 16/532,633 is a continuation of application No. 16/177,108, filed on Oct. 31, 2018, granted, now 10,722,481, issued on Jul. 28, 2020.
Application 16/177,108 is a continuation of application No. 15/567,334, abandoned, previously published as PCT/EP2016/058909, filed on Apr. 21, 2016.
Claims priority of application No. 20150514 (NO), filed on Apr. 28, 2015.
Prior Publication US 2024/0156760 A1, May 16, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/10 (2006.01); A61K 31/19 (2006.01); A61K 31/22 (2006.01); A61P 1/16 (2006.01); C07C 321/18 (2006.01)
CPC A61K 31/19 (2013.01) [A61K 31/22 (2013.01); A61P 1/16 (2018.01)] 20 Claims
 
1. A method for treating non-alcoholic steatohepatitis in a subject, wherein the method comprises administering to the subject in need thereof a pharmaceutical composition comprising at least one pharmaceutically acceptable excipient and a pharmaceutically effective amount of a compound of Formula (II):

OG Complex Work Unit Chemistry
or a pharmaceutically acceptable salt or stereoisomer thereof,
wherein:
R1 is C10-C22 alkenyl, wherein the C10-C22 alkenyl has 3, 4, 5, or 6 double bonds;
Y is —S—, —S(O)—, or —S(O)2—;
R2 is H, halogen, alkyl, alkenyl, acyl, C(O)OH, C(O)O(alkyl), NH2, NH(alkyl), OH, O(alkyl), O(acyl), S(alkyl), SO(alkyl), S(O)2(alkyl), or aryl;
R3 is H, halogen, alkyl, alkenyl, acyl, C(O)OH, C(O)O(alkyl), NH2, NH(alkyl), OH, O(alkyl), O(acyl), S(alkyl), SO(alkyl), S(O)2(alkyl), or aryl; or
R2 and R3, taken together with the carbon atom to which they are attached, form a C3-C6 cycloalkylidene; and
X is C(O)OH or C(O)OC1-C6 alkyl; or
X is:

OG Complex Work Unit Chemistry
with the proviso that R2 and R3 are not simultaneously H.