US 12,465,576 B2
Biotherapy for viral infections using biopolymer based micro/nanogels
Madhavan Nair, Coral Gables, FL (US); Andrea Raymond, Coconut Creek, FL (US); and Arti Vashist, Miami, FL (US)
Assigned to The Florida International University Board of Trustees, Miami, FL (US)
Filed by THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES, Miami, FL (US)
Filed on Apr. 1, 2025, as Appl. No. 19/097,443.
Application 18/950,649 is a division of application No. 17/615,940, granted, now 12,144,897, previously published as PCT/US2020/036292, filed on Jun. 5, 2020.
Application 19/097,443 is a continuation of application No. 18/950,649, filed on Nov. 18, 2024, granted, now 12,263,252.
Application 17/615,940 is a continuation in part of application No. 16/432,320, filed on Jun. 5, 2019, abandoned.
Prior Publication US 2025/0255830 A1, Aug. 14, 2025
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/51 (2006.01); A61K 9/107 (2006.01); A61K 9/20 (2006.01)
CPC A61K 9/5161 (2013.01) [A61K 9/1075 (2013.01); A61K 9/2081 (2013.01); A61K 9/5146 (2013.01)] 9 Claims
 
1. A method for drug delivery into a cell, the method comprising contacting the cell with biopolymer-based hydrogel nanoparticles, wherein the biopolymer-based hydrogel nanoparticles are loaded with a drug, and the biopolymer-based hydrogel nanoparticles have a core-shell structure and comprise a linseed oil polyol and one or more biopolymers selected from hydroxylpropylcellulose (HPC), carboxymethyl cellulose (CMC), methyl cellulose (MC), starches, pectin, chitosan, and hydroxyethyl cellulose (HEC).