US 12,465,520 B2
Apparatuses for drainage of degradable glaucoma capable of gradient control of scars and methods of making the same
Yong Wang, Chongqing (CN); and Xiangji Li, Chongqing (CN)
Assigned to CHONGQING UNIVERSITY, Chongqing (CN); and THE THIRD AFFILIATED HOSPITAL OF COMU (FANGDA HOSPITAL), Chongqing (CN)
Filed by CHONGQING UNIVERSITY, Chongqing (CN); and THE THIRD AFFILIATED HOSPITAL OF CQMU (FANGDA HOSPITAL), Chongqing (CN)
Filed on Mar. 19, 2025, as Appl. No. 19/083,513.
Application 19/083,513 is a continuation of application No. PCT/CN2023/139832, filed on Dec. 19, 2023.
Claims priority of application No. 202211642621.0 (CN), filed on Dec. 20, 2022.
Prior Publication US 2025/0221857 A1, Jul. 10, 2025
Int. Cl. A61F 9/007 (2006.01); A61K 9/70 (2006.01); A61K 31/407 (2006.01); A61L 31/14 (2006.01); A61L 31/16 (2006.01); A61P 27/06 (2006.01)
CPC A61F 9/00781 (2013.01) [A61K 9/7007 (2013.01); A61K 31/407 (2013.01); A61F 2210/0004 (2013.01); A61F 2240/001 (2013.01); A61F 2250/0067 (2013.01); A61L 31/148 (2013.01); A61L 31/16 (2013.01); A61L 2300/204 (2013.01); A61L 2420/02 (2013.01); A61P 27/06 (2018.01)] 3 Claims
OG exemplary drawing
 
1. An apparatus capable of gradient control of scars, configured for drainage of degradable glaucoma, comprising:
a long-strip-shaped drainage sheet with a uniform overall cross-sectional size, wherein:
the drainage sheet is made of a biodegradable material,
an outer surface of the drainage sheet is provided with a drainage gap that penetrates through opposite sides of the drainage sheet, the outer surface of the drainage sheet is coated with a biodegradable surface coating, and
the surface coating carries an anti-scarring drug, wherein the anti-scarring drug is configured to be gradually released as the surface coating degrades, a distribution concentration of the anti-scarring drug within the surface coating varies in a non-monotonic manner, the distribution concentration of the anti-scarring drug presents a distribution curve that, along a depth direction of the surface coating, first gradually decreases from a high point and then gradually increases, and reaches a highest point at a bottom of the surface coating.