US 12,465,272 B2
Vagus nerve stimulation system
Nathan Dundovic, Milton (AU); and Sophie Dundovic, Milton (AU)
Assigned to PARASYM LTD, London (GB)
Filed by PARASYM LTD, London (GB)
Filed on Dec. 11, 2023, as Appl. No. 18/535,628.
Application 18/535,628 is a continuation of application No. 17/634,954, previously published as PCT/AU2020/050838, filed on Aug. 12, 2020.
Claims priority of application No. 2019902913 (AU), filed on Aug. 13, 2019.
Prior Publication US 2024/0108273 A1, Apr. 4, 2024
Int. Cl. A61B 5/375 (2021.01); A61B 5/00 (2006.01); A61B 5/024 (2006.01); A61B 5/1495 (2006.01); A61N 1/04 (2006.01); A61B 5/01 (2006.01); A61B 5/0533 (2021.01); A61B 5/1455 (2006.01)
CPC A61B 5/375 (2021.01) [A61B 5/02438 (2013.01); A61B 5/1495 (2013.01); A61B 5/4836 (2013.01); A61B 5/486 (2013.01); A61B 5/6803 (2013.01); A61B 5/6838 (2013.01); A61N 1/0456 (2013.01); A61B 5/01 (2013.01); A61B 5/02405 (2013.01); A61B 5/0533 (2013.01); A61B 5/14551 (2013.01); A61B 5/681 (2013.01); A61B 5/7275 (2013.01); A61B 5/7455 (2013.01)] 24 Claims
OG exemplary drawing
 
1. A nerve stimulation system for stimulating a vagus nerve in a biological subject, the system comprising:
a) a securing member configured to be attached to the subject;
b) a signal generator electrically connected to electrodes, the signal generator being configured to generate at least one therapy signal that is configured to be applied to the vagus nerve via the securing member electrodes, to thereby modulate the vagus nerve of the subject for treating atrial fibrillation; and,
c) a controller being configured to:
i) cause the signal generator to generate progressively changing therapy signals having progressively changing therapy signal parameters;
ii) monitor a heart rate of the subject;
iii) detect changes in heart rate whilst the therapy signal parameters change;
iv) set a therapy signal parameter threshold based on one of the therapy signal parameters of the therapy signal when the changes in heart rate are detected; and,
v) cause the signal generator to generate therapy signals based on the therapy signal parameter threshold to thereby modulate the vagus nerve of the subject for treating atrial fibrillation.