| CPC A61B 5/14865 (2013.01) [A61B 5/14532 (2013.01)] | 20 Claims |

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1. An in-vivo analyte sensor comprising:
a working electrode comprising an active area disposed thereon, the active area including an analyte-responsive enzyme;
a scrubbing electrode, wherein the scrubbing electrode is positioned in a facing relationship to the active area of the working electrode and the working electrode and scrubbing electrode are separated by a layer between the working electrode and the scrubbing electrode and configured to permit bodily fluids to pass between the working electrode and scrubbing electrode, wherein the scrubbing electrode has a width greater than the working electrode and wherein the scrubbing electrode is configured to reduce a signal attributed to an interferent of the working electrode by pre-reacting the interferent before the interferent reaches the working electrode; and
an additional electrode, wherein the additional electrode is at least one of a counter electrode or a reference electrode, wherein the in-vivo analyte sensor is configured for in-vivo use.
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