US 12,465,247 B2
Identification and quantification of the degree of tissue hypoxia
Bruno Graversen, Hadsund (DK); Lisha Shastri, Aalborg (DK); Lars Pilegaard Thomsen, Skørping (DK); and Stephen Edward Rees, Gistrup (DK)
Assigned to Roche Diagnostics A/S, Copenhagen V (DK); and Aalborg Universitet, Aalborg Ost (DK)
Appl. No. 17/600,620
Filed by Roche Diagnostics A/S, Copenhagen V (DK); and AALBORG UNIVERSITET, Aalborg Øst (DK)
PCT Filed Apr. 6, 2020, PCT No. PCT/EP2020/059791
§ 371(c)(1), (2) Date Oct. 1, 2021,
PCT Pub. No. WO2020/207979, PCT Pub. Date Oct. 15, 2020.
Claims priority of application No. 19168646 (EP), filed on Apr. 11, 2019.
Prior Publication US 2022/0175283 A1, Jun. 9, 2022
Int. Cl. A61B 5/145 (2006.01); A61B 5/00 (2006.01); G16H 50/20 (2018.01)
CPC A61B 5/14542 (2013.01) [A61B 5/412 (2013.01); G16H 50/20 (2018.01)] 14 Claims
OG exemplary drawing
 
1. A method of determining a degree of tissue hypoxia of a subject and treating a determined tissue hypoxia in the subject, the method comprising:
determining venous blood values by at least one of measuring and estimating a blood acid-base status in a venous blood sample that has been obtained from the subject;
providing a value of at least one of measured and estimated arterial oxygenation (SO2AM, SO2AE, SpO2) from the subject;
converting the venous blood values by applying a venous-to-arterial conversion model for deriving blood acid-base status and oxygenation status into first estimated arterial blood values (1_ABGC);
providing second reference acid-base status and oxygenation values of arterial blood (2_ABG) from the subject;
implementing a tissue hypoxia model using at least one of a measure of the total buffer base concentration (BB) and a measure of the total carbon dioxide content (tCO2) in the arterial blood, the model having as input, at least the first estimated arterial blood values (1_ABGC) and the second reference values of arterial blood (2_ABG), wherein the tissue hypoxia model calculates at least one of:
a first measure indicative of the change in the total buffer base concentration (ΔBBT) between the first estimated arterial blood values (1_ABGC) and the second reference values of arterial blood (2_ABG); and
a second measure indicative of the change in the total carbon dioxide content (ΔtCO2,T) between the first estimated arterial blood values (1_ABGC) and the second reference values of arterial blood (2_ABG);
outputting, using the tissue hypoxia model, a measure indicative of the degree of tissue hypoxia of the subject using at least one of the first and second measures; and
treating the subject according to the measure indicative of the degree of tissue hypoxia, the treating comprising at least one of increasing a flow of oxygen to the subject and increasing a ventilation rate to the subject.