US 12,465,245 B2
Method of fabricating metasurface on skin for blood glucose detection
Zhiqing Xin, Beijing (CN); Qingfang Zhang, Beijing (CN); Yan Li, Beijing (CN); Yi Fang, Beijing (CN); Zhicheng Sun, Beijing (CN); Min Huang, Beijing (CN); Xiu Li, Beijing (CN); Lixin Mo, Beijing (CN); and Luhai Li, Beijing (CN)
Assigned to BEIJING INSTITUTE OF GRAPHIC COMMUNICATION, Beijing (CN)
Appl. No. 17/920,035
Filed by BEIJING INSTITUTE OF GRAPHIC COMMUNICATION, Beijing (CN)
PCT Filed Nov. 23, 2020, PCT No. PCT/CN2020/130933
§ 371(c)(1), (2) Date Oct. 20, 2022,
PCT Pub. No. WO2022/000956, PCT Pub. Date Jan. 6, 2022.
Claims priority of application No. 202010638269.8 (CN), filed on Jul. 3, 2020.
Prior Publication US 2023/0158822 A1, May 25, 2023
Int. Cl. A61B 5/145 (2006.01); A61B 5/1455 (2006.01); B41M 1/12 (2006.01); B41M 5/025 (2006.01); B41M 5/03 (2006.01)
CPC A61B 5/14532 (2013.01) [A61B 5/1455 (2013.01); B41M 1/12 (2013.01); B41M 5/025 (2013.01); B41M 5/03 (2013.01); A61B 2562/164 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A method of fabricating metasurface on skin for blood glucose detection, comprising:
designing a metasurface with a resonant ring structure cell, and building a model by simulating a relationship between blood glucose concentration and electromagnetic absorption property of the metasurface;
preparing the metasurface on the skin;
scanning the metasurface formed on the skin and acquiring reflection spectra of the metasurface under electromagnetic wave with different frequencies, thereby obtaining a relationship curve between S-11 parameter (reflection coefficient) and frequency; and
determining change of blood glucose concentration as a function of resonant peak frequency shift in the relationship curve based on the model;
wherein the preparing the metasurface on the skin comprises:
preparing a stretchable composite conductive ink using preset liquid metal particulates, preset metal particles, and preset elastic resin;
printing the stretchable composite conductive ink onto water transfer paper by screen printing, and applying preset treating pressure against the stretchable conductive ink layer printed on the water transfer paper for a preset duration after the ink is dry, such that shells of the liquid metal particulates in the stretchable composite conductive ink layer are cracked, and liquid metal particulates in the shell flow out to connect adjacent metal particles, thereby obtaining the metasurface on the water transfer paper; and
transferring the metasurface on the water transfer paper onto the skin via a water transfer printing process, whereby to form the metasurface on the skin.