US 12,465,239 B2
Systems and methods for screening asymptomatic virus emitters
David M. Palacios, Pasadena, CA (US); and Harry Hopper, Alexandria, VA (US)
Assigned to Hyperspectral Corp., Alexandria, VA (US)
Filed by Hyperspectral Corp., Alexandria, VA (US)
Filed on Jun. 10, 2024, as Appl. No. 18/738,790.
Application 18/738,790 is a continuation of application No. 17/238,052, filed on Apr. 22, 2021, granted, now 12,029,547.
Application 17/238,052 is a continuation of application No. 17/061,539, filed on Oct. 1, 2020, granted, now 11,925,456, issued on Mar. 12, 2024.
Claims priority of provisional application 63/080,653, filed on Sep. 18, 2020.
Claims priority of provisional application 63/017,618, filed on Apr. 29, 2020.
Prior Publication US 2024/0407667 A1, Dec. 12, 2024
Int. Cl. A61B 5/08 (2006.01); A61B 5/00 (2006.01); A61B 5/097 (2006.01); A61B 10/00 (2006.01); G01J 3/18 (2006.01); G01J 3/45 (2006.01); G01N 1/42 (2006.01); G01N 21/25 (2006.01); G01N 21/3504 (2014.01); G01N 21/359 (2014.01); G01N 33/497 (2006.01)
CPC A61B 5/082 (2013.01) [A61B 5/7282 (2013.01); A61B 10/00 (2013.01); G01J 3/18 (2013.01); G01J 3/45 (2013.01); G01N 1/42 (2013.01); G01N 21/255 (2013.01); G01N 21/3504 (2013.01); G01N 21/359 (2013.01); G01N 33/497 (2013.01); A61B 5/097 (2013.01); A61B 2010/0087 (2013.01); G01N 33/4975 (2024.05); G01N 2201/063 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A system comprising:
at least one processor; and
memory containing instructions to configure the at least one processor to perform the steps of:
identifying dark noise caused by changes in thermal energy of a first spectrometer by taking first measurements with the first spectrometer while projecting a first light through a transport medium;
normalizing the function of the first spectrometer by taking second measurements with the first spectrometer of a first known substance, identifying at least one peak spectral intensity of the second measurements and identifying a normalization adjustment such that the at least one peak spectral intensity is modified to be approximate to an expected spectral intensity for the first known substance, the normalization adjustment assisting in flat fielding a spectral sensor of the first spectrometer;
measuring first measurements using the first spectrometer by projecting a third light through a biological sample of a first patient and a vortex mask to create third measurements based on absorption and transmittance of the first light through the biological sample, the dark noise being removed from the first measurements and the normalization adjustment being applied to create the third measurements, the vortex mask providing destructive interference of the third light;
comparing the third measurements to a set of reference measurements; and
when a subset of the third measurements match or exceed at least a subset of the set of reference measurements, providing an alert indicating presence of a pathogen in the biological sample of the first patient.