US 12,465,229 B2
Facilitating assessment of blood flow and tissue perfusion using fluorescence-mediated photoplethysmography
Robert W. Flower, Hunt Valley, MD (US); Robert Anthony Stead, Vancouver (CA); and Arthur E. Bailey, North Vancouver (CA)
Assigned to Stryker Corporation, Portage, MI (US)
Filed by Stryker Corporation, Portage, MI (US)
Filed on Jul. 17, 2023, as Appl. No. 18/353,837.
Application 18/353,837 is a continuation of application No. 16/872,321, filed on May 11, 2020, granted, now 11,701,016.
Application 16/872,321 is a continuation of application No. 15/433,502, filed on Feb. 15, 2017, granted, now 10,646,128, issued on May 12, 2020.
Claims priority of provisional application 62/296,006, filed on Feb. 16, 2016.
Prior Publication US 2023/0355121 A1, Nov. 9, 2023
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/02 (2006.01); A61B 5/00 (2006.01); A61B 5/024 (2006.01); A61B 5/026 (2006.01); A61B 5/0275 (2006.01); A61B 5/029 (2006.01)
CPC A61B 5/0261 (2013.01) [A61B 5/0071 (2013.01); A61B 5/02416 (2013.01); A61B 5/0275 (2013.01); A61B 5/029 (2013.01); A61B 5/6826 (2013.01)] 22 Claims
OG exemplary drawing
 
1. A method for use in medical imaging for facilitating assessment of tissue perfusion in a tissue volume of a subject, the method comprising:
illuminating the tissue volume with visible light and with fluorescence excitation light, wherein the fluorescence excitation light excites a fluorescence agent in the tissue volume such that the excited fluorescence agent emits fluorescent light;
acquiring image data based at least in part on the fluorescent light emitted during blood flow through the tissue volume;
processing the image data to compensate for ambient light; and
generating an assessment of tissue perfusion in the tissue volume based at least in part on the processed image data.