US 12,465,045 B2
Lung perfusion solution, and use thereof for the ex-vivo preservation of a mammalian lung
Paul McLoughlin, County Dublin (IE); and Simon Coyle Rowan, Dublin (IE)
Assigned to UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN, Dublin (IE)
Filed by UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN, Dublin (IE)
Filed on Dec. 3, 2021, as Appl. No. 17/541,511.
Application 17/541,511 is a continuation of application No. 15/564,703, abandoned, previously published as PCT/EP2016/057846, filed on Apr. 8, 2016.
Claims priority of application No. 1505987 (GB), filed on Apr. 8, 2015.
Prior Publication US 2022/0338464 A1, Oct. 27, 2022
Int. Cl. A01N 1/165 (2025.01); A01N 1/126 (2025.01); A01N 1/143 (2025.01)
CPC A01N 1/126 (2025.01) [A01N 1/165 (2025.01); A01N 1/143 (2025.01)] 19 Claims
 
1. An organ perfusion solution comprising: a base solution comprising a physiological mixture of electrolytes and buffers; and 3.5-5.5% w/v a first macromolecule having a molecular weight of 40-100 kDa and an amount of a second, high molecular weight, macromolecule having a molecular weight of 350-600 kDa to adjust the relative viscosity of the organ perfusion solution to 2.1-2.7.