US 12,136,284 B2
Label-free hematology and pathology analysis using deep-ultraviolet microscopy
Francisco E. Robles, Atlanta, GA (US); and Ashkan Ojaghi, Atlanta, GA (US)
Assigned to Georgia Tech Research Corporation, Atlanta, GA (US)
Appl. No. 17/767,328
Filed by Georgia Tech Research Corporation, Atlanta, GA (US)
PCT Filed Oct. 13, 2020, PCT No. PCT/US2020/055431
§ 371(c)(1), (2) Date Apr. 7, 2022,
PCT Pub. No. WO2021/072408, PCT Pub. Date Apr. 15, 2021.
Claims priority of provisional application 62/915,495, filed on Oct. 15, 2019.
Claims priority of provisional application 62/913,611, filed on Oct. 10, 2019.
Prior Publication US 2022/0366709 A1, Nov. 17, 2022
Int. Cl. G06V 20/69 (2022.01); G01N 21/33 (2006.01); G01N 33/49 (2006.01); G02B 21/16 (2006.01); G02B 21/36 (2006.01); G06T 3/40 (2024.01); G06V 10/70 (2022.01); H04N 9/64 (2023.01); H04N 23/56 (2023.01)
CPC G06V 20/698 (2022.01) [G01N 21/33 (2013.01); G01N 33/49 (2013.01); G02B 21/16 (2013.01); G02B 21/365 (2013.01); G06T 3/40 (2013.01); G06V 10/70 (2022.01); G06V 20/693 (2022.01); G06V 20/695 (2022.01); H04N 9/64 (2013.01); H04N 23/56 (2023.01); G01N 2201/0621 (2013.01)] 16 Claims
OG exemplary drawing
 
1. A deep-ultraviolet imaging system comprising:
a broadband light source configured for outputting a light beam comprising ultraviolet wavelengths and non-ultraviolet wavelengths for illuminating a biological sample;
one or more band-pass filters configured for filtering the light beam output from the broadband light source to remove non-ultraviolet wavelengths and to relay ultraviolet wavelengths;
a reception space for reception of a biological sample for illumination by the light beam output from the one or more band-pass filters;
an ultraviolet imaging objective configured for:
collecting light that has interacted with the biological sample; and
relaying the collected light to an image capture device; and
an ultraviolet sensitive image capture device configured for capturing images of the light that is relayed from the ultraviolet imaging objective;
wherein the imaging system is configured to:
capture one or more images of the biological sample at one or more ultraviolet wavelengths; and
implement an analysis method on the one or more images to classify or characterize one or more cells in the biological sample.