US 12,136,211 B2
Fertilized egg development stage determination method, recording medium, imaging method and imaging apparatus
Ryo Hasebe, Kyoto (JP); Yasushi Kuromi, Kyoto (JP); Junichi Komiyama, Okayama (JP); and Osamu Okitsu, Tokyo (JP)
Assigned to SCREEN HOLDINGS CO., LTD., Kyoto (JP); and Miyake Clinic, Okayama (JP)
Filed by SCREEN Holdings Co., Ltd., Kyoto (JP); and Miyake Clinic, Okayama (JP)
Filed on Jan. 21, 2022, as Appl. No. 17/581,200.
Claims priority of application No. 2021-044304 (JP), filed on Mar. 18, 2021.
Prior Publication US 2022/0301155 A1, Sep. 22, 2022
Int. Cl. G06T 7/00 (2017.01); G06V 10/22 (2022.01); G06V 10/764 (2022.01)
CPC G06T 7/0012 (2013.01) [G06V 10/22 (2022.01); G06V 10/764 (2022.01); G06T 2207/10056 (2013.01); G06T 2207/10072 (2013.01); G06T 2207/10148 (2013.01); G06T 2207/30044 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A fertilized egg development stage determination method, comprising:
obtaining image data corresponding to an image of a fertilized egg captured by an optical microscope;
extracting a region corresponding to the fertilized egg in the image based on the image data and obtaining an index value indicating a degree of coincidence of the region with a circle;
extracting a region corresponding to a zona pellucida of the fertilized egg in the image based on the image data and obtaining an index value indicating a thickness of the region; and
determining a development stage of the fertilized egg based on the index value indicating the degree of coincidence, the index value indicating the thickness and determination criteria determined in advance for a combination of these index values,
wherein the determination criteria are determined based on:
the index values respectively obtained from images of a plurality of fertilized eggs and indicating the degree of coincidence; and
the thickness and information representing the development stage of each of the plurality of fertilized eggs, and
wherein the determination criteria divide a two-dimensional feature quantity space into a plurality of regions according to these index values and associate each region with the development stage, the two-dimensional feature quantity space having the index value indicating the degree of coincidence and the index value indicating the thickness respectively as feature quantities.