US 12,135,306 B2
Encoding state change of nanopore to reduce data size
Santiago Fernandez-Gomez, Sunnyvale, CA (US); Hui Tian, Cupertino, CA (US); Bill Maney, Emerald Hills, CA (US); and Seung Shin, San Jose, CA (US)
Assigned to Roche Sequencing Solutions, Inc., Pleasanton, CA (US)
Filed by Roche Sequencing Solutions, Inc., Pleasanton, CA (US)
Filed on Jan. 29, 2021, as Appl. No. 17/248,610.
Application 17/248,610 is a continuation of application No. 14/864,400, filed on Sep. 24, 2015, granted, now 10,935,512.
Prior Publication US 2021/0181139 A1, Jun. 17, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 27/40 (2006.01); G01N 33/487 (2006.01)
CPC G01N 27/40 (2013.01) [G01N 33/48721 (2013.01)] 17 Claims
OG exemplary drawing
 
1. A system, comprising:
a circuit configured to measure a first current at a first time, the first current corresponding to an electrical measurement of a nanopore, the circuit further configured to measure a second current at a second time, the second current corresponding to a second electrical measurement of the same nanopore; and
a component configured to compare the first current to the second current;
wherein based at least in part on the comparison of the first and second currents, a nanopore state change indicator is configured to determine whether a difference between the first current and the second current indicates a change in a state of the nanopore, and based at least in part on the determination of the nanopore state change indicator, it is periodically determined whether to provide as output a nanopore measurement value that can be used for a subsequent identification of a tag or molecule or to save data bandwidth by not outputting the nanopore measurement value.
 
17. A method, comprising:
measuring a first current corresponding to an electrical measurement of a nanopore;
comparing the first current measured at a first time to a second current corresponding to a second electrical measurement of the same nanopore measured at a second time;
determining, based at least in part on the comparison of the first and second currents measured at different times, a change in state of the nanopore with a nanopore state change indicator; and
based at least in part on the determination of the nanopore state change indicator, periodically determining whether to provide as output a nanopore measurement value that can be used for a subsequent identification of a tag or molecule or save data bandwidth by not outputting the nanopore measurement value.