US 12,135,291 B2
System for analog light measuring and photon counting in chemiluminescence measurements
Brian Kozicki, Saint Louis Park, MN (US); Creigh Thompson, Chaska, MN (US); Richard Wolf, Savage, MN (US); Laura Holmes, Minnetonka, MN (US); and David Sorrentino, Chaska, MN (US)
Assigned to Beckman Coulter, Inc., Brea, CA (US)
Filed by Beckman Coulter, Inc., Brea, CA (US)
Filed on Jul. 24, 2023, as Appl. No. 18/225,594.
Application 18/225,594 is a continuation of application No. 16/648,609, granted, now 11,754,504, previously published as PCT/US2018/051682, filed on Sep. 19, 2018.
Claims priority of provisional application 62/560,636, filed on Sep. 19, 2017.
Claims priority of provisional application 62/560,638, filed on Sep. 19, 2017.
Prior Publication US 2024/0027352 A1, Jan. 25, 2024
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 21/27 (2006.01); G01J 1/44 (2006.01); G01N 21/76 (2006.01)
CPC G01N 21/76 (2013.01) [G01J 1/44 (2013.01); G01N 21/27 (2013.01); G01N 21/272 (2013.01); G01J 2001/444 (2013.01); G01N 2201/022 (2013.01); G01N 2201/12753 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A system for performing an assay, the system comprising:
a chassis, comprising:
a reaction vessel chamber comprising
a first portion of a kinematic spherical joint adjacent to a bottom of the reaction vessel chamber, and
a first portion of a kinematic cylindrical joint adjacent to a top of the reaction vessel chamber, and
a light passage comprising a first end and a second end, the light passage intersecting the reaction vessel chamber;
a cap that, when in a closed configuration, forms a dark chamber by preventing light emitted by external light sources from entering the reaction vessel chamber and from entering the light passage, and, when in an open configuration, provides access to the reaction vessel chamber;
a calibration light source optically coupled to the first end of the light passage; and
a light detector optically coupled to the second end of the light passage, the light detector comprising
a sensing element for receiving light from the light passage, and
an aperture for receiving light from the light passage and that provides a shielded view of light from the light passage to the sensing element.