US 12,135,287 B2
Alarm method, system and storage medium for abnormalities of sample analyzer
Huan Qi, Shenzhen (CN); Wenbo Zheng, Shenzhen (CN); Bo Ye, Shenzhen (CN); Zhaoyang Li, Shenzhen (CN); and Yi Ye, Shenzhen (CN)
Filed by Shenzhen Mindray Bio-Medical Electronics Co., Ltd., Shenzhen (CN)
Filed on Oct. 9, 2023, as Appl. No. 18/377,880.
Application 18/377,880 is a continuation of application No. 17/078,705, filed on Oct. 23, 2020, granted, now 11,781,983.
Application 17/078,705 is a continuation of application No. PCT/CN2019/084686, filed on Apr. 26, 2019.
Claims priority of application No. PCT/CN2018/085198 (WO), filed on Apr. 28, 2018.
Prior Publication US 2024/0044793 A1, Feb. 8, 2024
Int. Cl. G01N 33/80 (2006.01); G01N 15/00 (2024.01); G01N 15/06 (2006.01); G01N 15/12 (2024.01); G01N 15/14 (2024.01); G01N 15/1429 (2024.01); G01N 15/1434 (2024.01); G01N 21/47 (2006.01); G01N 21/64 (2006.01); G01N 27/02 (2006.01); G01N 33/487 (2006.01); G08B 21/18 (2006.01); G01N 15/01 (2024.01); G01N 15/075 (2024.01); G01N 15/1404 (2024.01)
CPC G01N 21/6428 (2013.01) [G01N 15/06 (2013.01); G01N 15/1429 (2013.01); G01N 15/1436 (2013.01); G01N 21/47 (2013.01); G01N 27/02 (2013.01); G01N 33/48707 (2013.01); G01N 33/80 (2013.01); G08B 21/185 (2013.01); G01N 2015/011 (2024.01); G01N 2015/016 (2024.01); G01N 2015/018 (2024.01); G01N 15/075 (2024.01); G01N 2015/1402 (2013.01); G01N 15/1404 (2013.01); G01N 2021/6439 (2013.01)] 8 Claims
OG exemplary drawing
 
1. A blood analysis system, comprising:
a sample treatment device comprising at least one mixing chamber for mixing a first aliquot of a blood sample with a diluent agent to prepare a first test sample for first platelet detection, and for mixing a second aliquot of the blood sample with a lytic reagent to prepare a second test sample for second platelet detection, wherein red blood cells in the second test sample are lysed;
a sample detection device comprising an electrical impedance detection unit and an optical detection unit, wherein the electrical impedance detection unit includes an aperture and an electrical impedance detector, and the electrical impedance detector is configured to detect electrical impedance signals of the first test sample passing through the aperture, and the optical detection unit includes an optical flow chamber, a light source and an optical detector, wherein the optical flow chamber is in fluid communication with the at least one mixing chamber, the light source is configured to direct a light beam to the optical flow chamber, and the optical detector is configured to detect at least two types of optical signals of the second test sample passing through the optical flow chamber;
a data analysis module comprising a signal acquisition module, a classification and counting module and an alarm module;
wherein the signal acquisition module is configured to acquire the electrical impedance signals of the first test sample and the at least two types of optical signals of the second test sample;
the classification and counting module is configured to acquire first platelet detection data of the blood sample based on the electrical impedance signals, generate a scattergram of the second test sample based on the at least two types of optical signals, differentiate a white blood cell region from a platelet region in the scattergram based on the at least two types of optical signals, and acquire second platelet detection data of the blood sample based on the platelet region, wherein the first platelet detection data and the second platelet detection data comprise a same type of data selected from at least one of: a platelet count, a mean platelet volume, a platelet volume distribution width, or a platelet volume histogram; and
the alarm module is configured to calculate an evaluation value reflecting a difference degree between the first platelet detection data and the second platelet detection data, compare the evaluation value with a preset threshold, and provide an alarm for indicating that an abnormality is present in the first platelet detection and/or an abnormality is present in the electrical impedance detection unit, when the evaluation value is greater than the preset threshold.