US 12,135,286 B1
Optical biomodule for detection of diseases at an early onset
Mohammad A. Mazed, Yorba Linda, CA (US)
Filed by Mohammad A. Mazed, Yorba Linda, CA (US)
Filed on Jun. 15, 2022, as Appl. No. 17/803,387.
Application 17/803,387 is a continuation in part of application No. 16/602,966, filed on Jan. 6, 2020, granted, now 11,747,279.
Application 16/602,966 is a continuation in part of application No. 16/602,404, filed on Sep. 28, 2019, granted, now 11,320,588, issued on May 3, 2022.
Application 16/602,404 is a continuation in part of application No. 15/731,577, filed on Jul. 3, 2017, granted, now 10,529,003, issued on Jan. 7, 2020.
Application 15/731,577 is a continuation in part of application No. 14/999,601, filed on Jun. 1, 2016, granted, now 9,923,124, issued on Mar. 20, 2018.
Application 15/731,577 is a continuation in part of application No. 14/120,835, filed on Jul. 1, 2014, granted, now 9,823,737, issued on Nov. 21, 2017.
Application 15/731,577 is a continuation in part of application No. 13/448,378, filed on Apr. 16, 2012, granted, now 9,697,556, issued on Jul. 4, 2017.
Application 15/731,577 is a continuation in part of application No. 13/663,376, filed on Oct. 29, 2012, granted, now 9,557,271, issued on Jan. 31, 2017.
Application 13/663,376 is a continuation in part of application No. 13/135,832, filed on Jul. 15, 2011, abandoned.
Application 13/663,376 is a continuation in part of application No. 12/573,012, filed on Oct. 2, 2009, granted, now 8,017,147.
Application 13/663,376 is a continuation in part of application No. 12/931,384, filed on Jan. 31, 2011, granted, now 8,548,334.
Application 13/135,832 is a continuation in part of application No. 12/238,286, filed on Sep. 25, 2008, abandoned.
Application 13/135,832 is a continuation in part of application No. 11/952,001, filed on Dec. 6, 2007, granted, now 8,073,331.
Claims priority of provisional application 63/259,026, filed on Jun. 15, 2021.
Claims priority of provisional application 62/497,979, filed on Dec. 12, 2016.
Claims priority of provisional application 62/230,249, filed on Jun. 1, 2015.
Claims priority of provisional application 61/957,343, filed on Jul. 1, 2013.
Claims priority of provisional application 61/517,204, filed on Apr. 15, 2011.
Claims priority of provisional application 61/742,074, filed on Aug. 1, 2012.
Claims priority of provisional application 61/631,071, filed on Dec. 27, 2011.
Claims priority of provisional application 61/628,060, filed on Oct. 24, 2011.
Claims priority of provisional application 60/970,487, filed on Sep. 6, 2007.
Claims priority of provisional application 60/883,727, filed on Jan. 5, 2007.
Claims priority of provisional application 60/868,838, filed on Dec. 6, 2006.
Claims priority of provisional application 61/404,504, filed on Oct. 5, 2010.
This patent is subject to a terminal disclaimer.
Int. Cl. G01N 21/64 (2006.01); B01L 3/00 (2006.01); C12Q 1/6825 (2018.01); G01N 21/65 (2006.01); G01N 33/543 (2006.01)
CPC G01N 21/6428 (2013.01) [B01L 3/502761 (2013.01); C12Q 1/6825 (2013.01); G01N 21/65 (2013.01); G01N 33/54373 (2013.01); B01L 2200/0652 (2013.01); B01L 2300/0654 (2013.01); G01N 2021/6439 (2013.01)] 66 Claims
OG exemplary drawing
 
1. An optical biomodule comprising:
(a) a fluidic container;
wherein the fluidic container comprises a substrate,
wherein the substrate a substrate of the fluidic container comprises one or more (i) materials, or (ii) first metamaterials,
wherein the fluidic container further comprises a first biomarker binder, and a second biomarker binder,
wherein the first biomarker binder is coupled with a first fluorophore, or a first photoswitchable fluorophore,
wherein the second biomarker binder is coupled with a second fluorophore, or a second photoswitchable fluorophore,
wherein the first biomarker binder binds, or couples with a biomarker,
wherein the second biomarker binder binds, or couples with the biomarker,
wherein the fluidic container further comprises a plurality of three-dimensional (3-D) structures,
wherein the three-dimensional (3-D) structures are spaced or arranged in a one-dimensional (1-D) array, or in a two-dimensional (2-D) array,
wherein a pitch, or a gap, or a duty cycle of the one-dimensional (1-D) array, or the two-dimensional (2-D) array of the three-dimensional (3-D) structures is varied for a maximum enhancement of a fluorescence emission, or a light signal,
(b) a light source, or light sources for inducing the fluorescence emission, or the light signal; and
(c) a device for detecting the fluorescence emission, or the light signal, wherein the device comprises (i) a photodiode, or (ii) a light sensor.