US 12,135,261 B2
Automated tissue section capture, indexing and storage system and methods
Sean E. Anderson, Somerville, MA (US); Elijah Yew, Somerville, MA (US); Philip Knodle, Somerville, MA (US); and Timothy Ragan, Somerville, MA (US)
Assigned to TissueVision, Inc., Newton, MA (US)
Appl. No. 16/462,035
Filed by TissueVision, Inc., Somerville, MA (US)
PCT Filed Nov. 17, 2017, PCT No. PCT/US2017/062428
§ 371(c)(1), (2) Date May 17, 2019,
PCT Pub. No. WO2018/094290, PCT Pub. Date May 24, 2018.
Claims priority of provisional application 62/424,270, filed on Nov. 18, 2016.
Prior Publication US 2019/0301980 A1, Oct. 3, 2019
Int. Cl. G01N 1/00 (2006.01); G01N 1/06 (2006.01); G01N 35/00 (2006.01); G01N 35/04 (2006.01)
CPC G01N 1/06 (2013.01) [G01N 35/00029 (2013.01); G01N 35/00722 (2013.01); G01N 35/0099 (2013.01); G01N 35/04 (2013.01); G01N 2001/061 (2013.01); G01N 2035/00039 (2013.01); G01N 2035/0091 (2013.01)] 20 Claims
OG exemplary drawing
 
1. An automatic sample processing system comprising:
a sectioning tool to section, from a blockface of a tissue sample in a fluid bath, one or more tissue sections for processing;
a transport system to transport each tissue section separated from the tissue sample and removed from the fluid bath, the transport system including a tissue capture device that comprises a porous transport material and is further configured to provide a fluid flow within the fluid bath that directs a fluidic force at each tissue section such that each separated tissue section is received on the porous transport material that is actuated to move through the fluid bath and thereby removes each separated tissue section from the fluid bath;
a processing station that receives selected tissue sections transported from the fluid bath or from a storage system configured to store one or more tissue sections transported from the fluid bath;
an imaging device that images at least a portion of one or more tissue sections; and
a data processor that stores the images of the at least the imaged portion of each the one or more imaged tissue sections.