	US 12,134,770 B1
	Composition for regulating production of interfering ribonucleic acid
Bradley G. Thompson, Calgary (CA)
Assigned to Wyvern Pharmaceuticals Inc., Calgary (CA)
Filed by Wyvern Pharmaceuticals Inc., Calgary (CA)
Filed on Feb. 20, 2024, as Appl. No. 18/582,361.
Int. Cl. C12N 15/113 (2010.01); A61K 35/76 (2015.01); C12N 15/86 (2006.01)

CPC C12N 15/1138 (2013.01) [A61K 35/76 (2013.01); C12N 15/86 (2013.01); C12N 2310/141 (2013.01); C12N 2750/14143 (2013.01)]

15 Claims

1. A composition that comprises a recombinant plasmid (RP) with a sequence of nucleotides that comprise a start region, an end region and an insert positioned between the start region and the end region, in which the insert encodes for a sequence of micro-interfering ribonucleic acid (miRNA) that binds to and causes degradation of messenger ribonucleic acid (mRNA) that encodes for a dopamine receptor, wherein the insert sequence comprises 95-100% of the same nucleotide sequence as one of SEQ ID NO. 2, SEQ ID NO. 3, SEQ ID NO. 4 or SEQ ID NO. 5.