US 12,134,769 B2
MicroRNA-198 as a tumor suppressor in ovarian cancer
Qizhi Yao, Houston, TX (US); Christian Marin-Muller, League City, TX (US); and Changyi Chen, Houston, TX (US)
Assigned to Baylor College of Medicine, Houston, TX (US)
Filed by Baylor College of Medicine, Houston, TX (US)
Filed on Apr. 21, 2021, as Appl. No. 17/236,851.
Application 17/236,851 is a continuation of application No. 16/299,986, filed on Mar. 12, 2019, granted, now 11,008,573.
Application 16/299,986 is a continuation of application No. 15/955,451, filed on Apr. 17, 2018, abandoned.
Application 15/955,451 is a continuation of application No. 15/372,759, filed on Dec. 8, 2016, abandoned.
Application 15/372,759 is a continuation of application No. 14/615,168, filed on Feb. 5, 2015, granted, now 9,546,365, issued on Jan. 17, 2017.
Application 14/615,168 is a continuation of application No. 13/567,852, filed on Aug. 6, 2012, granted, now 8,987,224, issued on Mar. 24, 2015.
Claims priority of provisional application 61/515,416, filed on Aug. 5, 2011.
Prior Publication US 2022/0177889 A1, Jun. 9, 2022
Int. Cl. C12N 15/113 (2010.01); A61K 31/7088 (2006.01); A61K 31/7105 (2006.01); A61K 31/713 (2006.01); A61K 45/06 (2006.01); A61K 51/00 (2006.01); A61N 5/10 (2006.01)
CPC C12N 15/1135 (2013.01) [A61K 31/7088 (2013.01); A61K 31/7105 (2013.01); A61K 31/713 (2013.01); A61K 45/06 (2013.01); A61K 51/00 (2013.01); A61N 5/10 (2013.01); C12N 15/113 (2013.01); A61K 2300/00 (2013.01); C12N 2310/141 (2013.01); C12N 2320/30 (2013.01); C12N 2320/31 (2013.01); Y10S 977/704 (2013.01); Y10T 428/13 (2015.01)] 10 Claims
 
1. A method of treating cancer in an individual, comprising the step of delivering to the individual an effective amount of an agent that increases the level of microRNA-198 molecules in cancer cells of the individual, wherein the cancer is of the stomach or bone.