US 12,134,757 B2
Apparatus
Jian Ling, Spring Branch, TX (US); Kreg A. Zimmern, San Antonio, TX (US); and Michael C. Milone, Philadelphia, PA (US)
Assigned to Southwest Research Institute, San Antonio, TX (US); and The Trustees Of The University Of Pennsylvania, Philadelphia, PA (US)
Filed by Southwest Research Institute, San Antonio, TX (US); and The Trustees of the University of Pennsylvania, Philadelphia, PA (US)
Filed on Sep. 26, 2022, as Appl. No. 17/935,259.
Application 17/935,259 is a division of application No. 16/872,823, filed on May 12, 2020, granted, now 11,492,580.
Prior Publication US 2023/0012496 A1, Jan. 19, 2023
Int. Cl. C12M 1/00 (2006.01); A61K 39/00 (2006.01); B01L 3/00 (2006.01); C12M 1/12 (2006.01); C12N 5/00 (2006.01); C12N 5/0783 (2010.01); G01N 33/543 (2006.01)
CPC C12M 23/02 (2013.01) [A61K 39/4611 (2023.05); A61K 39/4631 (2023.05); A61K 39/464 (2023.05); C12M 23/20 (2013.01); C12M 25/00 (2013.01); C12N 5/0062 (2013.01); C12N 5/0636 (2013.01); G01N 33/54313 (2013.01); A61K 2239/38 (2023.05)] 21 Claims
OG exemplary drawing
 
1. An apparatus, comprising:
a plurality of spherical beads and a plurality of rods interconnecting the plurality of spherical beads, the plurality of rods assisting in providing spacing between the plurality of spherical beads that are adjacent to each other, wherein the diameter of the plurality of spherical beads is from about 10 μm to about 10 mm, the length of the plurality of rods is from about 0.1 μm to about 25 mm, the plurality of spherical beads and the plurality of rods are fixedly organized in two or more layers with each layer offset in x, y and z directions from an adjacent layer, the plurality of spherical beads and the plurality of rods being in a rotational fixed orientation,
the apparatus further comprising a protein coating on a surface of the apparatus.
 
15. An apparatus, comprising:
a plurality of spherical beads and a plurality of rods interconnecting the plurality of spherical beads, the plurality of rods assisting in providing spacing between the plurality of spherical beads that are adjacent to each other, wherein the diameter of the spherical beads is from about 10 μm to about 25 mm, the length of the rods is from about 0.1 μm to about 25 mm, the plurality of spherical beads and the plurality of rods are fixedly organized in two or more layers with each layer offset in x, y and z directions from an adjacent layer, the plurality of spherical beads and the plurality of rods being in a rotational fixed orientation,
the apparatus further comprising a protein coating on a surface of the apparatus.
 
19. An apparatus, comprising:
a plurality of spherical beads and a plurality of rods interconnecting the plurality of spherical beads, the plurality of rods assisting in providing spacing between the plurality of spherical beads that are adjacent to each other, wherein the diameter of the plurality of spherical beads is from about 10 μm to about 25 mm, the length of the plurality of rods is from about 0.1 μm to about 25 mm, the plurality of spherical beads and the plurality of rods are fixedly organized in a repeatable structure, the plurality of spherical beads and the plurality of rods are fixedly organized in two or more lavers with each layer offset in x, y and z directions from an adjacent layer, the plurality of spherical beads and the plurality of rods being in a rotational fixed orientation,
the apparatus further comprising a protein coating on a surface of the apparatus.