| CPC C07K 16/3061 (2013.01) [A61P 35/00 (2018.01); C07K 16/2827 (2013.01); C07K 16/2866 (2013.01); C07K 16/2893 (2013.01); C07K 16/2896 (2013.01); C07K 2317/31 (2013.01); C07K 2317/52 (2013.01); C07K 2317/76 (2013.01)] | 12 Claims |
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1. A multispecific antibody molecule comprising:
(i) a single anti-CSF1R binding moiety, wherein the anti-CSF1R binding moiety comprises three complementarity-determining regions (CDRs) from a heavy chain variable region sequence of: SEQ ID NO: 48, SEQ ID NO: 66, or SEQ ID NO: 69; and three CDRs from a light chain variable region sequence of: SEQ ID NO: 50, SEQ ID NO: 67, or SEQ ID NO: 70; and
(ii) an anti-CCR2 binding moiety, wherein the anti-CCR2 binding moiety comprise comprises three CDRs from a heavy chain variable region sequence of: SEQ ID NO: 44, SEQ ID NO: 54, SEQ ID NO: 59, SEQ ID NO: 62, or SEQ ID NO: 64; and three CDRs from a light chain variable region sequence of: SEQ ID NO: 45, SEQ ID NO: 57, SEQ ID NO: 60, SEQ ID NO: 63, or SEQ ID NO: 65;
wherein the multispecific antibody molecule:
binds to CSF1R monovalently,
does not reduce CSF1-dependent bone marrow-derived monocyte differentiation in vitro by more than 10%, and
does not reduce the number of tissue-resident macrophages in vivo by more than 15% when administered to a mammalian subject.
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