US 12,134,653 B2
Anti-CD40 antibodies and uses thereof
Yi Yang, Beijing (CN); Chunyan Dong, Beijing (CN); Fang Yang, Beijing (CN); Chengyuan Lu, Beijing (CN); Yuelei Shen, Beijing (CN); Jian Ni, Beijing (CN); Yanan Guo, Beijing (CN); Yunyun Chen, Beijing (CN); and Jingshu Xie, Beijing (CN)
Assigned to Eucure (Beijing) Biopharma Co., Ltd, Beijing (CN)
Filed by Eucure (Beijing) Biopharma Co., Ltd, Beijing (CN)
Filed on Sep. 8, 2021, as Appl. No. 17/469,488.
Application 17/469,488 is a division of application No. 17/149,209, filed on Jan. 14, 2021, granted, now 11,142,582.
Application 17/149,209 is a continuation of application No. PCT/CN2018/096494, filed on Jul. 20, 2018.
Prior Publication US 2021/0403588 A1, Dec. 30, 2021
Int. Cl. A61P 35/00 (2006.01); A61K 47/68 (2017.01); C07K 16/28 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/2878 (2013.01) [A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); A61P 35/00 (2018.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01)] 16 Claims
 
1. An antibody or antigen-binding fragment thereof that binds to CD40 comprising
a heavy chain variable region (VH) comprising an amino acid sequence that is identical to a selected VH sequence, and a light chain variable region (VL) comprising an amino acid sequence that is identical to a selected VL sequence, wherein the selected VH sequence and the selected VL sequence are one of the following:
(1) the selected VH sequence is SEQ ID NO: 30, 31, or 32, and the selected VL sequence is SEQ ID NO: 33, 34, 35, or 36;
(2) the selected VH sequence is SEQ ID NO: 37, 38, 39, or 40, and the selected VL sequence is SEQ ID NO: 41, 42, or 43; and
(3) the selected VH sequence is SEQ ID NO: 44, 45, 46, or 47, and the selected VL sequence is SEQ ID NO: 48, 49, 50, or 51;
(4) the selected VH sequence is SEQ ID NO: 52, and the selected VL sequence is SEQ ID NO: 53;
(5) the selected VH sequence is SEQ ID NO: 54, and the selected VL sequence is SEQ ID NO: 55; and
(6) the selected VH sequence is SEQ ID NO: 56, and the selected VL sequence is SEQ ID NO: 57.