CPC C07K 16/2878 (2013.01) [A61K 47/6803 (2017.08); A61K 47/6849 (2017.08); A61P 35/00 (2018.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01)] | 16 Claims |
1. An antibody or antigen-binding fragment thereof that binds to CD40 comprising
a heavy chain variable region (VH) comprising an amino acid sequence that is identical to a selected VH sequence, and a light chain variable region (VL) comprising an amino acid sequence that is identical to a selected VL sequence, wherein the selected VH sequence and the selected VL sequence are one of the following:
(1) the selected VH sequence is SEQ ID NO: 30, 31, or 32, and the selected VL sequence is SEQ ID NO: 33, 34, 35, or 36;
(2) the selected VH sequence is SEQ ID NO: 37, 38, 39, or 40, and the selected VL sequence is SEQ ID NO: 41, 42, or 43; and
(3) the selected VH sequence is SEQ ID NO: 44, 45, 46, or 47, and the selected VL sequence is SEQ ID NO: 48, 49, 50, or 51;
(4) the selected VH sequence is SEQ ID NO: 52, and the selected VL sequence is SEQ ID NO: 53;
(5) the selected VH sequence is SEQ ID NO: 54, and the selected VL sequence is SEQ ID NO: 55; and
(6) the selected VH sequence is SEQ ID NO: 56, and the selected VL sequence is SEQ ID NO: 57.
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