US 12,134,649 B2
Anti-B7-H4 antibodies and immunoconjugates
Steven R. Leong, Berkeley, CA (US); Andrew Polson, San Francisco, CA (US); Paul Polakis, Mill Valley, CA (US); Yan Wu, Foster City, CA (US); Wei-Ching Liang, Foster City, CA (US); and Ron Firestein, Burlingame, CA (US)
Assigned to Genentech, Inc., South San Francisco, CA (US)
Filed by Genentech, Inc., South San Francisco, CA (US)
Filed on Dec. 10, 2021, as Appl. No. 17/547,528.
Application 17/547,528 is a division of application No. 16/167,000, filed on Oct. 22, 2018, granted, now 11,230,600.
Application 16/167,000 is a division of application No. 14/773,334, granted, now 10,150,813, issued on Dec. 11, 2018, previously published as PCT/US2014/025285, filed on Mar. 13, 2014.
Claims priority of provisional application 61/874,175, filed on Sep. 5, 2013.
Claims priority of provisional application 61/785,811, filed on Mar. 14, 2013.
Claims priority of provisional application 61/784,877, filed on Mar. 14, 2013.
Prior Publication US 2022/0162318 A1, May 26, 2022
Int. Cl. C07K 16/28 (2006.01); A61K 38/08 (2019.01); A61K 39/395 (2006.01); A61K 47/65 (2017.01); A61K 47/68 (2017.01); A61K 51/10 (2006.01); A61P 35/00 (2006.01); C07K 16/30 (2006.01); G01N 33/569 (2006.01); A61K 39/00 (2006.01)
CPC C07K 16/2827 (2013.01) [A61K 38/08 (2013.01); A61K 39/39558 (2013.01); A61K 47/65 (2017.08); A61K 47/6801 (2017.08); A61K 47/6809 (2017.08); A61K 47/6849 (2017.08); A61K 47/6855 (2017.08); A61K 51/1027 (2013.01); A61K 51/1051 (2013.01); C07K 16/3015 (2013.01); G01N 33/56972 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/33 (2013.01); C07K 2317/56 (2013.01); C07K 2317/73 (2013.01); C07K 2317/77 (2013.01); C07K 2317/92 (2013.01)] 20 Claims
 
1. An isolated antibody that binds to B7-H4, wherein the antibody comprises:
(a)(i) HVR-H1 comprising the amino acid sequence of SEQ ID NO: 13, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO: 14, and (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO: 15.