	US 12,134,648 B2
	Dual specificity antibodies to human PD-L1 and PD-L2 and methods of use therefor
Michael A. Curran, Houston, TX (US); Ashvin R. Jaiswal, Houston, TX (US); Dongxing Zha, Houston, TX (US); Carlo Toniatti, Houston, TX (US); Bianka Prinz, Lebanon, NH (US); Nadthakarn Boland, Lebanon, NH (US); and Eric Krauland, Lebanon, NH (US)
Assigned to Board of Regents, The University of Texas System, Austin, TX (US)
Appl. No. 17/040,240
Filed by Board of Regents, The University of Texas System, Austin, TX (US)
PCT Filed Mar. 14, 2019, PCT No. PCT/US2019/022295 § 371(c)(1), (2) Date Sep. 22, 2020, PCT Pub. No. WO2019/182867, PCT Pub. Date Sep. 26, 2019.
Claims priority of provisional application 62/755,408, filed on Nov. 2, 2018.
Claims priority of provisional application 62/647,407, filed on Mar. 23, 2018.
Prior Publication US 2021/0139591 A1, May 13, 2021
Int. Cl. C07K 16/28 (2006.01); A61K 39/00 (2006.01); G01N 33/569 (2006.01); G01N 33/68 (2006.01)

CPC C07K 16/2827 (2013.01) [G01N 33/56966 (2013.01); G01N 33/6872 (2013.01); A61K 2039/505 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/565 (2013.01)]

16 Claims

1. An antibody or antigen binding fragment thereof comprising:

(a) heavy chain CDR1 sequence of SEQ ID NO: 27, heavy chain CDR2 sequence of SEQ ID NO: 28, and heavy chain CDR3 sequence of SEQ ID NO: 29; and light chain CDR1 sequence of SEQ ID NO: 45, light chain CDR2 sequence of SEQ ID NO: 46, and light chain CDR3 sequence of SEQ ID NO: 47;

(b) heavy chain CDR1 sequence of SEQ ID NO: 30, heavy chain CDR2 sequence of SEQ ID NO: 31 and heavy chain CDR3 sequence of SEQ ID NO: 32 and light chain CDR1 sequence of SEQ ID NO: 48, light chain CDR2 sequence of SEQ ID NO: 49 and light chain CDR3 sequence of SEQ ID NO: 50;

(c) heavy chain CDR1 sequence of SEQ ID NO: 33, heavy chain CDR2 sequence of SEQ ID NO: 34 and heavy chain CDR3 sequence of SEQ ID NO: 35 and light chain CDR1 sequence of SEQ ID NO: 51, light chain CDR2 sequence of SEQ ID NO: 52 and light chain CDR3 sequence of SEQ ID NO: 53;

(d) heavy chain CDR1 sequence of SEQ ID NO: 36, heavy chain CDR2 sequence of SEQ ID NO: 37 and heavy chain CDR3 sequence of SEQ ID NO: 38 and light chain CDR1 sequence of SEQ ID NO: 54, light chain CDR2 sequence of SEQ ID NO: 55 and light chain CDR3 sequence of SEQ ID NO: 56;

(e) heavy chain CDR1 sequence of SEQ ID NO: 39, heavy chain CDR2 sequence of SEQ ID NO: 40 and heavy chain CDR3 sequence of SEQ ID NO: 41 and light chain CDR1 sequence of SEQ ID NO: 57, light chain CDR2 sequence of SEQ ID NO: 58 and light chain CDR3 sequence of SEQ ID NO: 59;

(f) heavy chain CDR1 sequence of SEQ ID NO: 42, heavy chain CDR2 sequence of SEQ ID NO: 43, and heavy chain CDR3 sequence of SEQ ID NO: 44; and light chain CDR1 sequence of SEQ ID NO: 60, light chain CDR2 sequence of SEQ ID NO: 61 and light chain CDR3 sequence of SEQ ID NO: 62;

(g) heavy chain CDR1 sequence of SEQ ID NO: 72, heavy chain CDR2 sequence of SEQ ID NO: 73 and heavy chain CDR3 sequence of SEQ ID NO: 74 and light chain CDR1 sequence of SEQ ID NO: 87, light chain CDR2 sequence of SEQ ID NO: 88 and light chain CDR3 sequence of SEQ ID NO: 89;

(h) heavy chain CDR1 sequence of SEQ ID NO: 75, heavy chain CDR2 sequence of SEQ ID NO: 76 and heavy chain CDR3 sequence of SEQ ID NO: 77 and light chain CDR1 sequence of SEQ ID NO: 90, light chain CDR2 sequence of SEQ ID NO: 91 and light chain CDR3 sequence of SEQ ID NO: 92;

(i) heavy chain CDR1 sequence of SEQ ID NO: 78, heavy chain CDR2 sequence of SEQ ID NO: 79 and heavy chain CDR3 sequence of SEQ ID NO: 80 and light chain CDR1 sequence of SEQ ID NO: 93, light chain CDR2 sequence of SEQ ID NO: 94 and light chain CDR3 sequence of SEQ ID NO: 95;

(j) heavy chain CDR1 sequence of SEQ ID NO: 81, heavy chain CDR2 sequence of SEQ ID NO: 82 and heavy chain CDR3 sequence of SEQ ID NO: 83 and light chain CDR1 sequence of SEQ ID NO: 96, light chain CDR2 sequence of SEQ ID NO: 97 and light chain CDR3 sequence of SEQ ID NO: 98; or

(k) heavy chain CDR1 sequence of SEQ ID NO: 84, heavy chain CDR2 sequence of SEQ ID NO: 85 and heavy chain CDR3 sequence of SEQ ID NO: 86 and light chain CDR1 sequence of SEQ ID NO: 99, light chain CDR2 sequence of SEQ ID NO: 100 and light chain CDR3 sequence of SEQ ID NO: 101.