	US 12,134,645 B2
	Monoclonal antibodies against human tim-3
Xingxing Zang, New York, NY (US)
Assigned to ALBERT EINSTEIN COLLEGE OF MEDICINE, Bronx, NY (US)
Appl. No. 17/270,405
Filed by ALBERT EINSTEIN COLLEGE OF MEDICINE, Bronx, NY (US)
PCT Filed Aug. 21, 2019, PCT No. PCT/US2019/047573 § 371(c)(1), (2) Date Feb. 22, 2021, PCT Pub. No. WO2020/041520, PCT Pub. Date Feb. 27, 2020.
Claims priority of provisional application 62/720,234, filed on Aug. 21, 2018.
Prior Publication US 2021/0198357 A1, Jul. 1, 2021
Int. Cl. C07K 16/28 (2006.01); A61K 39/00 (2006.01); A61K 47/68 (2017.01)

CPC C07K 16/2803 (2013.01) [A61K 47/6849 (2017.08); A61K 2039/505 (2013.01); C07K 2317/565 (2013.01); C07K 2317/567 (2013.01); C07K 2317/92 (2013.01)]

11 Claims

1. An antibody or antigen-binding fragment thereof which binds to an IgV domain of a human Tim-3 (T cell immunoglobulin and mucin-domain containing-3) or IgV mucin-stalk of a human Tim-3, and comprises:

	GYSFTGYTIN (SEQ ID NO: 1) (HCDR1);

	LFNPYNGGTT (SEQ ID NO: 2 (HCDR2);

	ARRYYGYDAMDY (SEQ ID NO: 3) (HCDR3);

	KSSQSVLYSSNQKNHLA (SEQ ID NO: 4) (LCDR1);

	WASTRES (SEQ ID NO: 5) (LCDR2); and

	HQYLSSYT (SEQ ID NO: 6) (LCDR3); or

	GFNIKDYYMH (SEQ ID NO: 7) (HCDR1);

	WIDPENDNTIY (SEQ ID NO: 8) (HCDR2);

	ARDFGYVAWLVY (SEQ ID NO: 9) (HCDR3);

	KASQNVDTAVA (SEQ ID NO: 10) (LCDR1);

	SASNRYT (SEQ ID NO: 11) (LCDR2); and

	QQYSSYPT (SEQ ID NO: 12) (LCDR3).