	US 12,134,639 B2
	IL-15Rα sushi domain—IL-15 fusion proteins
Yannick Jacques, Nantes (FR); Ariane Plet, Nantes (FR); Erwan Mortier, Nantes (FR); Agnès Quemener, Nantes (FR); and Patricia Vusio, Saint Sébastien sur Loire (FR)
Assigned to INSERM (Institut National De La Santé Et De La Recherche Médicale, Paris (FR)
Filed by INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), Paris (FR)
Filed on Jun. 13, 2019, as Appl. No. 16/440,779.
Application 16/440,779 is a continuation of application No. 12/090,930, granted, now 10,358,477, previously published as PCT/IB2006/003917, filed on Oct. 6, 2006.
Claims priority of application No. 05292210 (EP), filed on Oct. 20, 2005.
Prior Publication US 2020/0109184 A1, Apr. 9, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 38/20 (2006.01); C07K 14/54 (2006.01); C07K 14/715 (2006.01)

CPC C07K 14/7155 (2013.01) [C07K 14/5443 (2013.01); C07K 2319/00 (2013.01)]

16 Claims

1. A fusion protein comprising an IL-15Rα sushi domain and an IL-15 which are joined by a flexible peptidic linker of 19 to 27 amino acids, wherein the IL-15Rα sushi domain comprises the amino acid sequence of SEQ ID NO:30 and the IL-15 comprises the amino acid sequence of SEQ ID NO:48, wherein the IL-15Rα sushi domain is in the N-terminal position relative to the IL-15.